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Repetitive Transcranial Magnetic Stimulation Improved Symptoms of Obsessive-Compulsive Disorder, But Also Cognitive Performance: Results From a Randomized Clinical Trial With a Cross-Over Design and Sham Condition Publisher Pubmed



Jahangard L1 ; Haghighi M1 ; Shyayganfard M1 ; Ahmadpanah M1 ; Sadeghi Bahmani D3 ; Bajoghli H2 ; Holsboertrachsler E3 ; Brand S3, 4
Authors

Source: Neuropsychobiology Published:2016


Abstract

Objective: There is some evidence that repetitive transcranial magnetic stimulation (rTMS) is an effective method of treating patients suffering from obsessive-compulsive disorder (OCD). Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and cognitive performance in such patients. Specifically, short-term verbal processing speed and flexibility were assessed. Method: Ten patients suffering from refractory OCD and treated with standard medication were randomly assigned either to a treatment-first or to a sham-first condition. At baseline and after 2 and 4 weeks, symptom severity (experts' ratings) and cognitive performance (auditory perception, visual perception, short-term memory, and processing speed) were assessed. After 2 weeks, the treatment condition switched to the sham condition, and the sham condition switched to the treatment condition. Results: Under treatment but not under sham conditions, symptom severity reduced. Moreover, cognitive performance improved in parallel. Conclusions: rTMS is a safe and efficient treatment for patients suffering from refractory OCD; symptoms and cognitive performance improved in parallel. © 2016 S. Karger AG, Basel.
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