Application of 5-Aminolevulinic Acid in Cancer Radio-Dynamic Therapy: A Systematic Review Publisher



Ahrabi H¹ ; Malekzadeh R² ; Geraily G¹
Source: Radiation Physics and Chemistry Published:2025

Abstract

Radio-dynamic therapy (RDT) is a targeted cancer treatment approach that involves the administration of a radio-sensitizing agent, followed by its activation using ionizing radiation, penetrating more deeply compared to the light used in photodynamic therapy (PDT). This systematic review aims to provide an overview of the current evidence on RDT using 5-aminolevulinic acid (5-ALA) for the treatment of various cancers. By comprehensively evaluating the relevant literature, the key findings, advantages, challenges, and future prospects of this therapeutic approach have been summarized. The review was conducted in accordance with the PRISMA guidelines, ensuring a comprehensive literature search across multiple electronic databases, including PubMed/MEDLINE, Embase, ProQuest, Scopus, and the Cochrane Library. The identified studies were then critically analyzed for their methodology, risk of bias, results, and implications. Within the review, the impact of factors such as dose, concentration, and cytotoxicity were examined in relation to the radiosensitizer 5-ALA. Additionally, the effects of radiation fraction, dose, and energy were explored in the context of RDT. By evaluating the current state of the research, this review provides insights into the clinical potential and limitations of RDT using porphyrin-based radiosensitizers. © 2025 Elsevier Ltd