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The Potential of 5-Aminolevulinic Acid As a Contrast Agent in Mr Imaging: Challenges and Opportunities Publisher



Ebrahimpour A1 ; Alam NR1 ; Khoobi M2, 3
Authors

Source: Journal of Sciences# Islamic Republic of Iran Published:2021


Abstract

Nowadays, 5-aminolevulinic acid (5-ALA) plays an influential role in the detection of malignant tumors as a photodynamic diagnosis tool. Nevertheless, an outlook regarding 5-ALA applicability in magnetic resonance imaging (MRI) has recently emerged. Many studies confirmed the impact of 5-ALA on promoting intracellular Heme synthesis and iron metabolism, which support the capability of 5-ALA in MRI owing to the susceptibility effect of iron. Therefore, concerning the high safety and high affinity of 5-ALA to tumor cells, 5-ALA-based MRI could be an intriguing method for malignant foci identification. © 2021 National Research Center of Medical Sciences. All rights reserved.
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