Effect of Omega-3 Fatty Acid Plus Vitamin E Co-Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis Publisher Pubmed



Sepidarkish M¹ ; Morvaridzadeh M² ; Akbarifakhrabadi M³ ; Almasihashiani A⁴ ; Rezaeinejad M⁵ ; Heshmati J²
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2019

Abstract

Background: Dyslipidemia is linked to chronic inflammation, which in return leads to a set of chronic disorders. Omega-3 fatty acids have been reported to reduce inflammation. Furthermore, Vitamin E is a fat-soluble vitamin which has antioxidant and anti-inflammatory effects. Vitamin E and omega-3 fatty acids co-supplementations may be more effective than the single supplementation in control dyslipidemia. Therefore, we designed and conducted the current systematic review and meta-analysis to investigate the effect of co-supplementation of vitamin E and omega-3 fatty acids on the lipid profile. Methods: A comprehensive search for studies published between January 1990 and July 2018 was performed. The initial search extracted 3015 potentially relevant articles. After studying these publications, 9 RCTs were potentially eligible and retrieved in full text. Results: The meta-analysis indicate that on total cholesterol, HDL, LDL and triglyceride individually did not show any significant difference between intervention and control groups, but vitamin E an omega-3 fatty acids co-supplementations significantly reduce VLDL levels. Conclusions: Based on the available evidence, omega-3 fatty acid and vitamin E co-supplementation can reduce VLDL, although its effect on other lipid profile parameters requires more well-designed studies. © 2019 Diabetes India