Effects of Vitamin D Supplementation on Omentin-1 and Spexin Levels, Inflammatory Parameters, Lipid Profile, and Anthropometric Indices in Obese and Overweight Adults With Vitamin D Deficiency Under Low-Calorie Diet: A Randomized Placebo Controlled Trial Publisher



Cheshmazar E¹ ; Hosseini AF² ; Yazdani B³ ; Razmpoosh E^{4, 5} ; Zarrati M¹
Source: Evidence-based Complementary and Alternative Medicine Published:2020

Abstract

Background and Aims. Improved vitamin D levels can have a favorable effect on some metabolic variables. The objective of the current study was to determine the effects of vitamin D supplementation during a weight-loss intervention on the levels of omentin-1, spexin, lipid profiles, and inflammatory factors in obese and overweight participants. Methods and Materials. In this double-blind placebo-controlled randomized clinical trial, 70 overweight and obese participants with vitamin D deficiency (25(OH)D ≤ 20 nmol/L) were assigned into the intervention (a daily dose of 2,000 IU vitamin D + low-calorie diet) and placebo (placebo + low-calorie diet) groups for 8 weeks. Anthropometric parameters, serum levels of 25-hydroxy vitamin D (25(OH)D), lipid profiles, omentin-1 and spexin levels, high-sensitivity C-reactive protein (hs-CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations were assessed before and after the intervention. Results. Vitamin D supplementation after the intervention led to a significant decrease in triglycerides (TG) (P=0.02), very-low-density lipoprotein-cholesterol (VLDL-C) (P=0.02), and hs-CRP (P=0.03) concentrations and a significant increase in the serum vitamin D level (P<0.001). Furthermore, after adjusting for baseline values, age, and baseline BMI, the levels of serum high-density lipoprotein-cholesterol (HDL-C) (P=0.01) increased significantly, and a significant reduction was observed in the concentration of sICAM-1 (P=0.01) in the intervention group. However, we did not find any significant difference in serum omentin-1 and spexin concentrations between the groups after intervention. Conclusions. Vitamin D supplementation along with a low-calorie diet (LCD) program for 8 weeks significantly decreased the inflammatory markers in obese individuals, while it did not alter serum omentin-1 and spexin concentrations. © 2020 Elhameh Cheshmazar et al.