Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression

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Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression Publisher Pubmed

Nikkhoo A^{1, 2} ; Rostami N¹ ; Farhadi S³ ; Esmaily M⁴ ; Moghadaszadeh Ardebili S¹ ; Atyabi F⁵ ; Baghaei M⁵ ; Haghnavaz N⁶ ; Yousefi M⁷ ; Aliparasti MR¹ ; Ghalamfarsa G⁸ ; Mohammadi H⁹ ; Sojoodi M¹⁰ ; Jadidiniaragh F^{1, 11}

Source: International Journal of Pharmaceutics Published:2020

Abstract

High expression of inhibitor of apoptosis (IAP) molecules in cancer cells promotes cancer cell chemoresistance. Use of BV6, a well-known IAP inhibitor, along with inhibition of signal transducer and activator of transcription 3 (STAT3), which is an important factor in the survival of tumor cells, and NIK as a mediator of BV6 unpredicted side effects, can induce effective apoptosis in tumor cells. The present study has investigated the combination therapy of cancer cells using Carboxymethyl Dextran-conjugated trimethyl chitosan (TMC-CMD) nanoparticles (NPs) loaded with NIK/STAT3-specific siRNA and BV6 to synergistically induce apoptosis in the breast, colorectal and melanoma cancer cell lines. Our results showed that in addition to enhanced pro-apoptotic effects, this combination therapy reduced proliferation, cell migration, colony formation, and angiogenesis, along with expression of factors including IL-10 and HIF in tumor cells. The results indicate the potential of this combination therapy for further investigation in animal models of cancer. © 2020 Elsevier B.V.

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Style	Citing Format
MLA	Nikkhoo A, et al.. "Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression." International Journal of Pharmaceutics, vol. 581, no. , 2020, pp. -.
APA	Nikkhoo A, Rostami N, Farhadi S, Esmaily M, Moghadaszadeh Ardebili S, Atyabi F, Baghaei M, Haghnavaz N, Yousefi M, Aliparasti MR, Ghalamfarsa G, Mohammadi H, Sojoodi M, Jadidiniaragh F (2020). Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression. International Journal of Pharmaceutics, 581(), -.
Chicago	Nikkhoo A, Rostami N, Farhadi S, Esmaily M, Moghadaszadeh Ardebili S, Atyabi F, Baghaei M, et al.. "Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression." International Journal of Pharmaceutics 581, no. (2020): -.
Harvard	Nikkhoo A et al. (2020) 'Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression', International Journal of Pharmaceutics, 581(), pp. -.
Vancouver	Nikkhoo A, Rostami N, Farhadi S, Esmaily M, Moghadaszadeh Ardebili S, Atyabi F, et al.. Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression. International Journal of Pharmaceutics. 2020;581():-.
BibTex	@article{ author = {Nikkhoo A and Rostami N and Farhadi S and Esmaily M and Moghadaszadeh Ardebili S and Atyabi F and Baghaei M and Haghnavaz N and Yousefi M and Aliparasti MR and Ghalamfarsa G and Mohammadi H and Sojoodi M and Jadidiniaragh F}, title = {Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression}, journal = {International Journal of Pharmaceutics}, volume = {581}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Nikkhoo A AU - Rostami N AU - Farhadi S AU - Esmaily M AU - Moghadaszadeh Ardebili S AU - Atyabi F AU - Baghaei M AU - Haghnavaz N AU - Yousefi M AU - Aliparasti MR AU - Ghalamfarsa G AU - Mohammadi H AU - Sojoodi M AU - Jadidiniaragh F TI - Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression JO - International Journal of Pharmaceutics VL - 581 IS - SP - EP - PY - 2020 ER -

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