Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Combination Cancer Immunotherapy With Dendritic Cell Vaccine and Nanoparticles Loaded With Interleukin-15 and Anti-Beta-Catenin Sirna Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response Publisher Pubmed



Kheshti AMS1 ; Hajizadeh F2 ; Barshidi A1 ; Rashidi B1 ; Ebrahimi F3 ; Bahmanpour S1 ; Karpisheh V1 ; Noukabadi FK4 ; Kiani FK1 ; Hassannia H5 ; Atyabi F6 ; Kiaie SH1, 7 ; Kashanchi F8 ; Navashenaq JG9 Show All Authors
Authors
  1. Kheshti AMS1
  2. Hajizadeh F2
  3. Barshidi A1
  4. Rashidi B1
  5. Ebrahimi F3
  6. Bahmanpour S1
  7. Karpisheh V1
  8. Noukabadi FK4
  9. Kiani FK1
  10. Hassannia H5
  11. Atyabi F6
  12. Kiaie SH1, 7
  13. Kashanchi F8
  14. Navashenaq JG9
  15. Mohammadi H10
  16. Bagherifar R7
  17. Jafari R11, 12
  18. Zolbanin NM12, 13, 14
  19. Jadidiniaragh F1, 15, 16

Source: Pharmaceutical Research Published:2022


Abstract

Purpose: The invention and application of new immunotherapeutic methods can compensate for the inefficiency of conventional cancer treatment approaches, partly due to the inhibitory microenvironment of the tumor. In this study, we tried to inhibit the growth of cancer cells and induce anti-tumor immune responses by silencing the expression of the β-catenin in the tumor microenvironment and transmitting interleukin (IL)-15 cytokine to provide optimal conditions for the dendritic cell (DC) vaccine. Methods: For this purpose, we used folic acid (FA)-conjugated SPION-carboxymethyl dextran (CMD) chitosan (C) nanoparticles (NPs) to deliver anti-β-catenin siRNA and IL-15 to cancer cells. Results: The results showed that the codelivery of β-catenin siRNA and IL-15 significantly reduced the growth of cancer cells and increased the immune response. The treatment also considerably stimulated the performance of the DC vaccine in triggering anti-tumor immunity, which inhibited tumor development and increased survival in mice in two different cancer models. Conclusions: These findings suggest that the use of new nanocarriers such as SPION-C-CMD-FA could be an effective way to use as a novel combination therapy consisting of β-catenin siRNA, IL-15, and DC vaccine to treat cancer. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Simultaneous Inhibition of Cd73 and Il-6 Molecules by Sirna-Loaded Nanoparticles Prevents the Growth and Spread of Cancer, Nanomedicine: Nanotechnology# Biology# and Medicine (2021)
2. Increased Susceptibility to Doxorubicin-Induced Cell Death in Acute Lymphocytic Leukemia Cells by Inhibiting Serine/Threonine Wee1 Kinase Expression Using the Chitosan-Carboxymethyl Dextran-Polyethylene Glycol-Tat Nanoparticles, Journal of Drug Delivery Science and Technology (2022)
3. Silencing of Hif-1Α/Cd73 Axis by Sirna-Loaded Tat-Chitosan-Spion Nanoparticles Robustly Blocks Cancer Cell Progression, European Journal of Pharmacology (2020)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (15)
Nima Rezaei (1)
Other Related Docs
4. Inhibition of Hif-1Α/Ep4 Axis by Hyaluronate-Trimethyl Chitosan-Spion Nanoparticles Markedly Suppresses the Growth and Development of Cancer Cells, International Journal of Biological Macromolecules (2021)
5. Nanomedicine for Improvement of Dendritic Cell-Based Cancer Immunotherapy, International Immunopharmacology (2020)
6. Silencing Adenosine A2a Receptor Enhances Dendritic Cell-Based Cancer Immunotherapy, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
7. Combined Inhibition of Cd73 and Zeb1 by Arg-Gly-Asp (Rgd)-Targeted Nanoparticles Inhibits Tumor Growth, Colloids and Surfaces B: Biointerfaces (2021)
8. Silencing of Il-6 and Stat3 by Sirna Loaded Hyaluronate-N,N,N-Trimethyl Chitosan Nanoparticles Potently Reduces Cancer Cell Progression, International Journal of Biological Macromolecules (2020)
9. Inhibition of Cd73 Using Folate Targeted Nanoparticles Carrying Anti-Cd73 Sirna Potentiates Anticancer Efficacy of Dinaciclib, Life Sciences (2020)
10. Blockade of Ctla-4 Increases Anti-Tumor Response Inducing Potential of Dendritic Cell Vaccine, Journal of Controlled Release (2020)
11. Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression, International Journal of Pharmaceutics (2020)
12. Concomitant Blockade of A2ar and Ctla-4 by Sirna-Loaded Polyethylene Glycol-Chitosan-Alginate Nanoparticles Synergistically Enhances Antitumor T-Cell Responses, Journal of Cellular Physiology (2020)
13. Blockage of Immune Checkpoint Molecules Increases T-Cell Priming Potential of Dendritic Cell Vaccine, Immunology (2020)
14. Nano-Immunotherapy: Overcoming Delivery Challenge of Immune Checkpoint Therapy, Journal of Nanobiotechnology (2023)
15. Downregulation of A2ar by Sirna Loaded Peg-Chitosan-Lactate Nanoparticles Restores the T Cell Mediated Anti-Tumor Responses Through Blockage of Pka/Creb Signaling Pathway, International Journal of Biological Macromolecules (2019)
16. Carboxymethyl Dextran-Trimethyl Chitosan Coated Superparamagnetic Iron Oxide Nanoparticles: An Effective Sirna Delivery System for Hiv-1 Nef, Journal of Cellular Physiology (2019)
17. Development of a T Cell-Targeted Sirna Delivery System Against Hiv-1 Using Modified Superparamagnetic Iron Oxide Nanoparticles: An in Vitro Study, Journal of Pharmaceutical Sciences (2022)
18. Codelivery of Hif-1Α Sirna and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression, Pharmaceutical Research (2020)
19. Macrophage’S Role in Solid Tumors: Two Edges of a Sword, Cancer Cell International (2023)
20. Tumor Immunology, Clinical Immunology (2022)