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Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management Publisher Pubmed



Yazdani R1 ; Habibi S1 ; Sharifi L2 ; Azizi G3 ; Abolhassani H4, 5 ; Olbrich P6 ; Aghamohammadi A1
Authors

Source: Journal of Investigational Allergology and Clinical Immunology Published:2020


Abstract

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency, with a wide variety of infectious and noninfectious complications. Numerous studies have demonstrated that immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss various aspects of CVID, including epidemiology, pathogenesis, symptoms, diagnosis, classification, and management. © 2020 Esmon Publicidad.
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