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Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors Publisher



Rayatzadeh A1 ; Saeedi M3 ; Mahdavi M2 ; Rezaei Z2 ; Sabourian R3 ; Mosslemin MH1 ; Akbarzadeh T2, 3 ; Foroumadi A2 ; Shafiee A2
Authors

Source: Monatshefte fur Chemie Published:2015


Abstract

An efficient synthetic route for the synthesis of novel oxoisoindoline derivatives was described through Ugi reaction of 2-formylbenzoic acids, amines, and isocyanides. All compounds were evaluated for their acetylcholinesterase inhibitory activity and among them, 2 of 12 tested compounds showed good activity as compared to other derivatives. Graphical Abstract: [Figure not available: see fulltext.]. © 2014 Springer-Verlag Wien.
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