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Immune Cells Involved in the Pathogenesis of Ankylosing Spondylitis Publisher Pubmed



Rezaiemanesh A1 ; Abdolmaleki M2 ; Abdolmohammadi K2 ; Aghaei H2 ; Pakdel FD2 ; Fatahi Y3 ; Soleimanifar N4 ; Zavvar M2 ; Nicknam MH2, 4
Authors

Source: Biomedicine and Pharmacotherapy Published:2018


Abstract

Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS. © 2018
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