Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis

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Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis Publisher Pubmed

Dashti N^{1, 2} ; Mahmoudi M¹ ; Aslani S¹ ; Jamshidi A¹

Source: Gene Published:2018

Abstract

Ankylosing spondylitis (AS) is a highly heritable kind of arthritis that affects the vertebral column. AS risk has been associated strongly with Human leukocyte antigen (HLA)-B*27. In fact, some HLA-B*27 subtypes have been associated with the increased disease risk, although some specific subtypes have not shown such associations. It is supposed that HLA-B*27 plays a major role in the etiopathogenesis of the disease. However, the difference in pathogenic outcomes of HLA-B*27 certain subtypes needs to be clarified. The purpose of this review article is to overview on the detailed implications of the HLA-B*27 subtypes in the etiopathogenesis of AS. Moreover, the role of ERAP1 in AS and its epistasis with HLA-B*27 have been reviewed. © 2018 Elsevier B.V.

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Style	Citing Format
MLA	Dashti N, et al.. "Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis." Gene, vol. 670, no. , 2018, pp. 15-21.
APA	Dashti N, Mahmoudi M, Aslani S, Jamshidi A (2018). Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis. Gene, 670(), 15-21.
Chicago	Dashti N, Mahmoudi M, Aslani S, Jamshidi A. "Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis." Gene 670, no. (2018): 15-21.
Harvard	Dashti N et al. (2018) 'Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis', Gene, 670(), pp. 15-21.
Vancouver	Dashti N, Mahmoudi M, Aslani S, Jamshidi A. Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis. Gene. 2018;670():15-21.
BibTex	@article{ author = {Dashti N and Mahmoudi M and Aslani S and Jamshidi A}, title = {Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis}, journal = {Gene}, volume = {670}, number = {}, pages = {15-21}, year = {2018} }
RIS	TY - JOUR AU - Dashti N AU - Mahmoudi M AU - Aslani S AU - Jamshidi A TI - Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis JO - Gene VL - 670 IS - SP - 15 EP - 21 PY - 2018 ER -

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