Lack of Association Between Monocyte Chemoattractant Protein-1 (Mcp-1) Gene Promoter Polymorphism and Behcet’S Disease With and Without Ocular Involvement in Iranian Population: A Case–Control Study Publisher Pubmed



Ghaffari Laleh M¹ ; Bonyadi M¹ ; Shahriyari E¹ ; Jabbarpoor Bonyadi MH² ; Soheilian M² ; Yaseri M³
Source: Current Eye Research Published:2022

Abstract

Purpose: This case-control study aimed to evaluate the possible association of MCP-1 − 2518A/G genetic polymorphism with Behcet’s disease (BD) in the Iranian patients. Materials and methods: This study was performed in 135 Behcet’s patients (51 ocular and 84 non-ocular) and 79 healthy individuals. Peripheral blood samples were genotyped for MCP-1 − 2518A/G using the PCR-RFLP technique. Results: The statistical analysis of MCP-1 − 2518A/G showed no significant differences in genotype/allele frequencies between Behcet’s patients and controls. There was no significant association in genotype/allele frequencies between either ocular or non-ocular BD patients and controls. Also, different genotype/allele frequencies between ocular and non-ocular BD were not statistically significant. Conclusions: In this study, with a threshold P-value of 0.05 and an estimated power of 0.81 to detect a significant association (odds ratio ≥1.2), we did not observe any association of this variant with Behcet's disease. © 2021 Taylor & Francis Group, LLC.