Tumor Necrosis Factor (Tnf)-308, -1031, and Angiotensin-Converting Enzyme (Ace) Dd/Ii Polymorphisms’ Role in Behcet’S Disease With and Without Uveitis: A Meta-Analysis Publisher Pubmed



Jabbarpoor Bonyadi MH¹ ; Yaseri M² ; Soheilian M¹
Source: Ophthalmic Genetics Published:2020

Abstract

Purpose: There are conflicting results of studies investigating the association between the tumor necrosis factor (TNF) and angiotensin-converting enzyme (ACE) gene polymorphisms and Behcet’s disease (BD). The aim of this meta-analysis is to assess the association between these gene polymorphisms and ocular involvement in BD. Methods: We identified relevant studies and reviewed the full-text manuscripts of the studies in order to select those for inclusion. Heterogeneity of studies was evaluated using Cochran Q-test and I-square index. To modify the heterogeneity in the variables we used random effects model. Meta-analysis was performed using STATA. Results: We analyzed TNF-1031, −308 and ACE DD/II genotype difference between BD patients with and without uveitis. Among these polymorphic genetic loci TNF-308 AA genotype has a statistically significant protective effect against BD uveitis (OR = 0.45 vs 1.23, p = .017). Such a statistically significant effect was not seen for other studied genotypes. Conclusion: This meta-analysis revealed a significant protective effect of TNF-308 AA genotype against ocular involvement in Behcet’s disease. © 2020, © 2020 Taylor & Francis Group, LLC.