Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program

Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program Publisher Pubmed

Robbins HA¹ ; Alcala K¹ ; Moez EK² ; Guida F³ ; Thomas S² ; Zahed H¹ ; Warkentin MT^{2, 4} ; Smithbyrne K⁵ ; Brhane Y² ; Muller D⁶ ; Feng X¹ ; Albanes D⁷ ; Aldrich MC⁸ ; Arslan AA⁹ Show All Authors

Robbins HA¹
Alcala K¹
Moez EK²
Guida F³
Thomas S²
Zahed H¹
Warkentin MT^{2, 4}
Smithbyrne K⁵
Brhane Y²
Muller D⁶
Feng X¹
Albanes D⁷
Aldrich MC⁸
Arslan AA⁹
Bassett J¹⁰
Berg CD¹¹
Cai Q¹²
Chen C¹³
Davies MPA¹⁴
Diergaarde B^{15, 16}
Field JK¹⁴
Freedman ND⁷
Huang WY⁷
Johansson M¹⁷
Jones M¹⁸
Koh WP^{19, 20}
Lam S²¹
Lan Q⁷
Langhammer A^{22, 23}
Liao LM⁷
Liu G²⁴
Malekzadeh R²⁵
Milne RL^{10, 26, 27}
Montuenga LM^{28, 29, 30}
Rohan T³¹
Sesso HD³²
Severi G³³
Sheikh M¹
Sinha R⁷
Shu XO¹²
Stevens VL³⁴
Tammemagi MC^{35, 36}
Tinker LF³⁷
Visvanathan K³⁸
Wang Y³⁹
Wang R⁴⁰
Weinstein SJ⁷
White E⁴¹
Wilson D⁴²
Yuan JM^{16, 43}
Zhang X³²
Zheng W¹²
Amos CI⁴⁴
Brennan P¹
Johansson M¹⁷
Hung RJ^{2, 4}

Source: Annals of Epidemiology Published:2023

Abstract

The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies. © 2022

Related Docs

View other Related Docs

1. Lung Cancer Risk Prediction Models for Asian Ever-Smokers, Journal of Thoracic Oncology (2024)

2. Expression Analysis of P16, C-Myc, and Msin3a in Non-Small Cell Lung Cancer by Computer Aided Scoring and Analysis (Casa), Clinical Laboratory (2015)

3. Expression of Two Basic Mrna Biomarkers in Peripheral Blood of Patients With Non-Small Cell Lung Cancer Detected by Real-Time Rt-Pcr, Individually and Simultaneously, Iranian Biomedical Journal (2015)

Experts (# of related papers)

View all Related Experts

Naghmeh Bahrami (10)

Reza Malekzadeh (2)

Style	Citing Format
MLA	Robbins HA, et al.. "Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program." Annals of Epidemiology, vol. 77, no. , 2023, pp. 1-12.
APA	Robbins HA, Alcala K, Moez EK, Guida F, Thomas S, Zahed H, Warkentin MT, Smithbyrne K, Brhane Y, Muller D, Feng X, Albanes D, Aldrich MC, Arslan AA, Bassett J, Berg CD, Cai Q, Chen C, Davies MPA, ... Hung RJ (2023). Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program. Annals of Epidemiology, 77(), 1-12.
Chicago	Robbins HA, Alcala K, Moez EK, Guida F, Thomas S, Zahed H, Warkentin MT, et al.. "Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program." Annals of Epidemiology 77, no. (2023): 1-12.
Harvard	Robbins HA et al. (2023) 'Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program', Annals of Epidemiology, 77(), pp. 1-12.
Vancouver	Robbins HA, Alcala K, Moez EK, Guida F, Thomas S, Zahed H, et al.. Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program. Annals of Epidemiology. 2023;77():1-12.
BibTex	@article{ author = {Robbins HA and Alcala K and Moez EK and Guida F and Thomas S and Zahed H and Warkentin MT and Smithbyrne K and Brhane Y and Muller D and Feng X and Albanes D and Aldrich MC and Arslan AA and Bassett J and Berg CD and Cai Q and Chen C and Davies MPA and Diergaarde B and Field JK and Freedman ND and Huang WY and Johansson M and Jones M and Koh WP and Lam S and Lan Q and Langhammer A and Liao LM and Liu G and Malekzadeh R and Milne RL and Montuenga LM and Rohan T and Sesso HD and Severi G and Sheikh M and Sinha R and Shu XO and Stevens VL and Tammemagi MC and Tinker LF and Visvanathan K and Wang Y and Wang R and Weinstein SJ and White E and Wilson D and Yuan JM and Zhang X and Zheng W and Amos CI and Brennan P and Johansson M and Hung RJ}, title = {Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program}, journal = {Annals of Epidemiology}, volume = {77}, number = {}, pages = {1-12}, year = {2023} }
RIS	TY - JOUR AU - Robbins HA AU - Alcala K AU - Moez EK AU - Guida F AU - Thomas S AU - Zahed H AU - Warkentin MT AU - Smithbyrne K AU - Brhane Y AU - Muller D AU - Feng X AU - Albanes D AU - Aldrich MC AU - Arslan AA AU - Bassett J AU - Berg CD AU - Cai Q AU - Chen C AU - Davies MPA AU - Diergaarde B AU - Field JK AU - Freedman ND AU - Huang WY AU - Johansson M AU - Jones M AU - Koh WP AU - Lam S AU - Lan Q AU - Langhammer A AU - Liao LM AU - Liu G AU - Malekzadeh R AU - Milne RL AU - Montuenga LM AU - Rohan T AU - Sesso HD AU - Severi G AU - Sheikh M AU - Sinha R AU - Shu XO AU - Stevens VL AU - Tammemagi MC AU - Tinker LF AU - Visvanathan K AU - Wang Y AU - Wang R AU - Weinstein SJ AU - White E AU - Wilson D AU - Yuan JM AU - Zhang X AU - Zheng W AU - Amos CI AU - Brennan P AU - Johansson M AU - Hung RJ TI - Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program JO - Annals of Epidemiology VL - 77 IS - SP - 1 EP - 12 PY - 2023 ER -

Style

Citing Format

MLA

Robbins HA, et al.. "Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program." Annals of Epidemiology, vol. 77, no. , 2023, pp. 1-12.

APA

Robbins HA, Alcala K, Moez EK, Guida F, Thomas S, Zahed H, Warkentin MT, Smithbyrne K, Brhane Y, Muller D, Feng X, Albanes D, Aldrich MC, Arslan AA, Bassett J, Berg CD, Cai Q, Chen C, Davies MPA, ... Hung RJ (2023). Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program. Annals of Epidemiology, 77(), 1-12.

Chicago

Robbins HA, Alcala K, Moez EK, Guida F, Thomas S, Zahed H, Warkentin MT, et al.. "Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program." Annals of Epidemiology 77, no. (2023): 1-12.

Harvard

Robbins HA et al. (2023) 'Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program', Annals of Epidemiology, 77(), pp. 1-12.

Vancouver

Robbins HA, Alcala K, Moez EK, Guida F, Thomas S, Zahed H, et al.. Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program. Annals of Epidemiology. 2023;77():1-12.

BibTex

@article{ author = {Robbins HA and Alcala K and Moez EK and Guida F and Thomas S and Zahed H and Warkentin MT and Smithbyrne K and Brhane Y and Muller D and Feng X and Albanes D and Aldrich MC and Arslan AA and Bassett J and Berg CD and Cai Q and Chen C and Davies MPA and Diergaarde B and Field JK and Freedman ND and Huang WY and Johansson M and Jones M and Koh WP and Lam S and Lan Q and Langhammer A and Liao LM and Liu G and Malekzadeh R and Milne RL and Montuenga LM and Rohan T and Sesso HD and Severi G and Sheikh M and Sinha R and Shu XO and Stevens VL and Tammemagi MC and Tinker LF and Visvanathan K and Wang Y and Wang R and Weinstein SJ and White E and Wilson D and Yuan JM and Zhang X and Zheng W and Amos CI and Brennan P and Johansson M and Hung RJ}, title = {Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program}, journal = {Annals of Epidemiology}, volume = {77}, number = {}, pages = {1-12}, year = {2023} }

RIS

TY - JOUR
AU - Robbins HA
AU - Alcala K
AU - Moez EK
AU - Guida F
AU - Thomas S
AU - Zahed H
AU - Warkentin MT
AU - Smithbyrne K
AU - Brhane Y
AU - Muller D
AU - Feng X
AU - Albanes D
AU - Aldrich MC
AU - Arslan AA
AU - Bassett J
AU - Berg CD
AU - Cai Q
AU - Chen C
AU - Davies MPA
AU - Diergaarde B
AU - Field JK
AU - Freedman ND
AU - Huang WY
AU - Johansson M
AU - Jones M
AU - Koh WP
AU - Lam S
AU - Lan Q
AU - Langhammer A
AU - Liao LM
AU - Liu G
AU - Malekzadeh R
AU - Milne RL
AU - Montuenga LM
AU - Rohan T
AU - Sesso HD
AU - Severi G
AU - Sheikh M
AU - Sinha R
AU - Shu XO
AU - Stevens VL
AU - Tammemagi MC
AU - Tinker LF
AU - Visvanathan K
AU - Wang Y
AU - Wang R
AU - Weinstein SJ
AU - White E
AU - Wilson D
AU - Yuan JM
AU - Zhang X
AU - Zheng W
AU - Amos CI
AU - Brennan P
AU - Johansson M
AU - Hung RJ
TI - Design and Methodological Considerations for Biomarker Discovery and Validation in the Integrative Analysis of Lung Cancer Etiology and Risk (Integral) Program
JO - Annals of Epidemiology
VL - 77
IS -
SP - 1
EP - 12
PY - 2023
ER -

Science Communicator Platform

Authors

Abstract