Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2

Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2 Publisher Pubmed

Hassan SS¹ ; Attrish D² ; Ghosh S³ ; Choudhury PP⁴ ; Uversky VN⁵ ; Aljabali AAA⁶ ; Lundstrom K⁷ ; Uhal BD⁸ ; Rezaei N^{9, 26} ; Seyran M¹⁰ ; Pizzol D¹¹ ; Adadi P¹² ; Soares A¹³ ; Abd Elaziz TM^{13, 14} Show All Authors

Hassan SS¹
Attrish D²
Ghosh S³
Choudhury PP⁴
Uversky VN⁵
Aljabali AAA⁶
Lundstrom K⁷
Uhal BD⁸
Rezaei N^{9, 26}
Seyran M¹⁰
Pizzol D¹¹
Adadi P¹²
Soares A¹³
Abd Elaziz TM^{13, 14}
Kandimalla R^{15, 27}
Tambuwala MM¹⁶
Azad GK¹⁷
Sherchan SP¹⁸
Baetasdacruz W¹⁹
Lal A²⁰
Palu G²¹
Takayama K²²
Serranoaroca A²³
Barh D²⁴
Brufsky AM²⁵

Source: International Journal of Biological Macromolecules Published:2021

Abstract

The current Coronavirus Disease 19 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) shows similar pathology to MERS and SARS-CoV, with a current estimated fatality rate of 1.4%. Open reading frame 10 (ORF10) is a unique SARS-CoV-2 accessory protein, which contains eleven cytotoxic T lymphocyte (CTL) epitopes each of nine amino acids in length. Twenty-two unique SARS-CoV-2 ORF10 variants have been identified based on missense mutations found in sequence databases. Some of these mutations are predicted to decrease the stability of ORF10 in silico physicochemical and structural comparative analyses were carried out on SARS-CoV-2 and Pangolin-CoV ORF10 proteins, which share 97.37% amino acid (aa) homology. Though there is a high degree of ORF10 protein similarity of SARS-CoV-2 and Pangolin-CoV, there are differences of these two ORF10 proteins related to their sub-structure (loop/coil region), solubility, antigenicity and shift from strand to coil at aa position 26 (tyrosine). SARS-CoV-2 ORF10, which is apparently expressed in vivo since reactive T cell clones are found in convalescent patients should be monitored for changes which could correlate with the pathogenesis of COVID-19. © 2021 Elsevier B.V.

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Style	Citing Format
MLA	Hassan SS, et al.. "Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2." International Journal of Biological Macromolecules, vol. 181, no. , 2021, pp. 801-809.
APA	Hassan SS, Attrish D, Ghosh S, Choudhury PP, Uversky VN, Aljabali AAA, Lundstrom K, Uhal BD, Rezaei N, Seyran M, Pizzol D, Adadi P, Soares A, Abd Elaziz TM, Kandimalla R, Tambuwala MM, Azad GK, Sherchan SP, Baetasdacruz W, ... Brufsky AM (2021). Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2. International Journal of Biological Macromolecules, 181(), 801-809.
Chicago	Hassan SS, Attrish D, Ghosh S, Choudhury PP, Uversky VN, Aljabali AAA, Lundstrom K, et al.. "Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2." International Journal of Biological Macromolecules 181, no. (2021): 801-809.
Harvard	Hassan SS et al. (2021) 'Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2', International Journal of Biological Macromolecules, 181(), pp. 801-809.
Vancouver	Hassan SS, Attrish D, Ghosh S, Choudhury PP, Uversky VN, Aljabali AAA, et al.. Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2. International Journal of Biological Macromolecules. 2021;181():801-809.
BibTex	@article{ author = {Hassan SS and Attrish D and Ghosh S and Choudhury PP and Uversky VN and Aljabali AAA and Lundstrom K and Uhal BD and Rezaei N and Seyran M and Pizzol D and Adadi P and Soares A and Abd Elaziz TM and Kandimalla R and Tambuwala MM and Azad GK and Sherchan SP and Baetasdacruz W and Lal A and Palu G and Takayama K and Serranoaroca A and Barh D and Brufsky AM}, title = {Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2}, journal = {International Journal of Biological Macromolecules}, volume = {181}, number = {}, pages = {801-809}, year = {2021} }
RIS	TY - JOUR AU - Hassan SS AU - Attrish D AU - Ghosh S AU - Choudhury PP AU - Uversky VN AU - Aljabali AAA AU - Lundstrom K AU - Uhal BD AU - Rezaei N AU - Seyran M AU - Pizzol D AU - Adadi P AU - Soares A AU - Abd Elaziz TM AU - Kandimalla R AU - Tambuwala MM AU - Azad GK AU - Sherchan SP AU - Baetasdacruz W AU - Lal A AU - Palu G AU - Takayama K AU - Serranoaroca A AU - Barh D AU - Brufsky AM TI - Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2 JO - International Journal of Biological Macromolecules VL - 181 IS - SP - 801 EP - 809 PY - 2021 ER -

Style

Citing Format

MLA

Hassan SS, et al.. "Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2." International Journal of Biological Macromolecules, vol. 181, no. , 2021, pp. 801-809.

APA

Hassan SS, Attrish D, Ghosh S, Choudhury PP, Uversky VN, Aljabali AAA, Lundstrom K, Uhal BD, Rezaei N, Seyran M, Pizzol D, Adadi P, Soares A, Abd Elaziz TM, Kandimalla R, Tambuwala MM, Azad GK, Sherchan SP, Baetasdacruz W, ... Brufsky AM (2021). Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2. International Journal of Biological Macromolecules, 181(), 801-809.

Chicago

Hassan SS, Attrish D, Ghosh S, Choudhury PP, Uversky VN, Aljabali AAA, Lundstrom K, et al.. "Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2." International Journal of Biological Macromolecules 181, no. (2021): 801-809.

Harvard

Hassan SS et al. (2021) 'Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2', International Journal of Biological Macromolecules, 181(), pp. 801-809.

Vancouver

Hassan SS, Attrish D, Ghosh S, Choudhury PP, Uversky VN, Aljabali AAA, et al.. Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2. International Journal of Biological Macromolecules. 2021;181():801-809.

BibTex

@article{ author = {Hassan SS and Attrish D and Ghosh S and Choudhury PP and Uversky VN and Aljabali AAA and Lundstrom K and Uhal BD and Rezaei N and Seyran M and Pizzol D and Adadi P and Soares A and Abd Elaziz TM and Kandimalla R and Tambuwala MM and Azad GK and Sherchan SP and Baetasdacruz W and Lal A and Palu G and Takayama K and Serranoaroca A and Barh D and Brufsky AM}, title = {Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2}, journal = {International Journal of Biological Macromolecules}, volume = {181}, number = {}, pages = {801-809}, year = {2021} }

RIS

TY - JOUR
AU - Hassan SS
AU - Attrish D
AU - Ghosh S
AU - Choudhury PP
AU - Uversky VN
AU - Aljabali AAA
AU - Lundstrom K
AU - Uhal BD
AU - Rezaei N
AU - Seyran M
AU - Pizzol D
AU - Adadi P
AU - Soares A
AU - Abd Elaziz TM
AU - Kandimalla R
AU - Tambuwala MM
AU - Azad GK
AU - Sherchan SP
AU - Baetasdacruz W
AU - Lal A
AU - Palu G
AU - Takayama K
AU - Serranoaroca A
AU - Barh D
AU - Brufsky AM
TI - Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2
JO - International Journal of Biological Macromolecules
VL - 181
IS -
SP - 801
EP - 809
PY - 2021
ER -

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