The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2

The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2 Publisher Pubmed

Hassan SS¹ ; Choudhury PP² ; Aljabali AAA⁴ ; Uhal BD⁵ ; Lundstrom K⁶ ; Rezaei N^{7, 32} ; Pizzol D⁸ ; Adadi P⁹ ; Lal A¹⁰ ; Soares A¹¹ ; Mohamed Abd Elaziz T^{11, 12} ; Brufsky AM¹³ ; Azad GK¹⁴ ; Sherchan SP¹⁵ Show All Authors

Hassan SS¹
Choudhury PP²
Aljabali AAA⁴
Uhal BD⁵
Lundstrom K⁶
Rezaei N^{7, 32}
Pizzol D⁸
Adadi P⁹
Lal A¹⁰
Soares A¹¹
Mohamed Abd Elaziz T^{11, 12}
Brufsky AM¹³
Azad GK¹⁴
Sherchan SP¹⁵
Baetasdacruz W¹⁶
Takayama K¹⁷
Serranoaroca A¹⁸
Chauhan G¹⁹
Palu G²⁰
Mishra YK²¹
Barh D^{22, 23}
Santana Silva RJ²⁴
Andrade BS²⁵
Azevedo V²³
Goesneto A²⁶
Bazan NG²⁷
Redwan EM²⁸
Tambuwala M²⁹
Uversky VN^{30, 31}

Source: Archives of Biochemistry and Biophysics Published:2022

Abstract

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. © 2022 Elsevier Inc.

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Nima Rezaei (7)

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Style	Citing Format
MLA	Hassan SS, et al.. "The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2." Archives of Biochemistry and Biophysics, vol. 717, no. , 2022, pp. -.
APA	Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, Pizzol D, Adadi P, Lal A, Soares A, Mohamed Abd Elaziz T, Brufsky AM, Azad GK, Sherchan SP, Baetasdacruz W, Takayama K, Serranoaroca A, Chauhan G, Palu G, ... Uversky VN (2022). The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2. Archives of Biochemistry and Biophysics, 717(), -.
Chicago	Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, Pizzol D, et al.. "The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2." Archives of Biochemistry and Biophysics 717, no. (2022): -.
Harvard	Hassan SS et al. (2022) 'The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2', Archives of Biochemistry and Biophysics, 717(), pp. -.
Vancouver	Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, et al.. The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2. Archives of Biochemistry and Biophysics. 2022;717():-.
BibTex	@article{ author = {Hassan SS and Choudhury PP and Aljabali AAA and Uhal BD and Lundstrom K and Rezaei N and Pizzol D and Adadi P and Lal A and Soares A and Mohamed Abd Elaziz T and Brufsky AM and Azad GK and Sherchan SP and Baetasdacruz W and Takayama K and Serranoaroca A and Chauhan G and Palu G and Mishra YK and Barh D and Santana Silva RJ and Andrade BS and Azevedo V and Goesneto A and Bazan NG and Redwan EM and Tambuwala M and Uversky VN}, title = {The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2}, journal = {Archives of Biochemistry and Biophysics}, volume = {717}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Hassan SS AU - Choudhury PP AU - Aljabali AAA AU - Uhal BD AU - Lundstrom K AU - Rezaei N AU - Pizzol D AU - Adadi P AU - Lal A AU - Soares A AU - Mohamed Abd Elaziz T AU - Brufsky AM AU - Azad GK AU - Sherchan SP AU - Baetasdacruz W AU - Takayama K AU - Serranoaroca A AU - Chauhan G AU - Palu G AU - Mishra YK AU - Barh D AU - Santana Silva RJ AU - Andrade BS AU - Azevedo V AU - Goesneto A AU - Bazan NG AU - Redwan EM AU - Tambuwala M AU - Uversky VN TI - The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2 JO - Archives of Biochemistry and Biophysics VL - 717 IS - SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Hassan SS, et al.. "The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2." Archives of Biochemistry and Biophysics, vol. 717, no. , 2022, pp. -.

APA

Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, Pizzol D, Adadi P, Lal A, Soares A, Mohamed Abd Elaziz T, Brufsky AM, Azad GK, Sherchan SP, Baetasdacruz W, Takayama K, Serranoaroca A, Chauhan G, Palu G, ... Uversky VN (2022). The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2. Archives of Biochemistry and Biophysics, 717(), -.

Chicago

Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, Pizzol D, et al.. "The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2." Archives of Biochemistry and Biophysics 717, no. (2022): -.

Harvard

Hassan SS et al. (2022) 'The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2', Archives of Biochemistry and Biophysics, 717(), pp. -.

Vancouver

Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, et al.. The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2. Archives of Biochemistry and Biophysics. 2022;717():-.

BibTex

@article{ author = {Hassan SS and Choudhury PP and Aljabali AAA and Uhal BD and Lundstrom K and Rezaei N and Pizzol D and Adadi P and Lal A and Soares A and Mohamed Abd Elaziz T and Brufsky AM and Azad GK and Sherchan SP and Baetasdacruz W and Takayama K and Serranoaroca A and Chauhan G and Palu G and Mishra YK and Barh D and Santana Silva RJ and Andrade BS and Azevedo V and Goesneto A and Bazan NG and Redwan EM and Tambuwala M and Uversky VN}, title = {The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2}, journal = {Archives of Biochemistry and Biophysics}, volume = {717}, number = {}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Hassan SS
AU - Choudhury PP
AU - Aljabali AAA
AU - Uhal BD
AU - Lundstrom K
AU - Rezaei N
AU - Pizzol D
AU - Adadi P
AU - Lal A
AU - Soares A
AU - Mohamed Abd Elaziz T
AU - Brufsky AM
AU - Azad GK
AU - Sherchan SP
AU - Baetasdacruz W
AU - Takayama K
AU - Serranoaroca A
AU - Chauhan G
AU - Palu G
AU - Mishra YK
AU - Barh D
AU - Santana Silva RJ
AU - Andrade BS
AU - Azevedo V
AU - Goesneto A
AU - Bazan NG
AU - Redwan EM
AU - Tambuwala M
AU - Uversky VN
TI - The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2
JO - Archives of Biochemistry and Biophysics
VL - 717
IS -
SP -
EP -
PY - 2022
ER -

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