Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share By

Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis Publisher Pubmed

Babaie F^{1, 2} ; Mohammadi H^{3, 4} ; Salimi S^{5, 6} ; Ghanavatinegad A⁷ ; Abbasifard M^{8, 9} ; Yousefi M¹⁰ ; Hajaliloo M¹¹ ; Khalili Y¹² ; Zamanlou S¹² ; Safari R¹³ ; Hemmatzadeh M¹⁰ ; Rezaiemanesh A¹⁴ ; Salimi R¹⁵ ; Baradaran B^{5, 10} Show All Authors

Babaie F^{1, 2}
Mohammadi H^{3, 4}
Salimi S^{5, 6}
Ghanavatinegad A⁷
Abbasifard M^{8, 9}
Yousefi M¹⁰
Hajaliloo M¹¹
Khalili Y¹²
Zamanlou S¹²
Safari R¹³
Hemmatzadeh M¹⁰
Rezaiemanesh A¹⁴
Salimi R¹⁵
Baradaran B^{5, 10}
Babaloo Z^{5, 10, 11}

Source: Clinical Immunology Published:2023

Abstract

Background: We aimed to assess if Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms might impress Human leukocyte antigen (HLA)-B27-free heavy chains (FHCs) expression on macrophages and eventually NK cell activation in Ankylosing spondylitis (AS). Methods: Blood samples were obtained from 10 HLA[sbnd]B27+ patients with protective and 10 HLA[sbnd]B27+ patients with non-protective genotype. Monocytes were isolated and polarized toward M1 and M2 macrophages. ERAP1 was inhibited in macrophages, which were then co-cultured with autologous NK cells. Results: Expression of HLA-B27-FHCs on M1 and M2 macrophages was reduced in patients with protective ERAP1 genotype. Co-culturing ERAP1-inhibited M1 macrophages and NK cells from patients with protective genotype resulted in downmodulation of CD69 and CD107a markers on NK cells and reduced number of IFN-γ+ NK cells compared to that of patients with non-protective genotypes. Conclusion: Inhibition of ERAP1 activity, by diminishing NK activation, may have therapeutic value in treating AS patients. © 2023 Elsevier Inc.

Related Docs

View other Related Docs

1. The Roles of Erap1 and Erap2 in Autoimmunity and Cancer Immunity: New Insights and Perspective, Molecular Immunology (2020)

2. Endoplasmic Reticulum Aminopeptidase 2 Gene Single Nucleotide Polymorphisms in Association With Susceptibility to Ankylosing Spondylitis in an Iranian Population, Immunology Letters (2020)

3. Immunopathogenesis of Ankylosing Spondylitis: An Updated Review, Acta Medica Iranica (2018)

Experts (# of related papers)

View all Related Experts

Ahmad Reza Jamshidi (11)

Mahdi Mahmoudi (11)

Other Related Docs

4. Association of the Genetic Variants in the Endoplasmic Reticulum Aminopeptidase 2 Gene With Ankylosing Spondylitis Susceptibility, International Journal of Rheumatic Diseases (2021)

5. Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis, Gene (2018)

6. Innate Immune-Related Cells and Cytokines in Spondyloarthropathies, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)

7. Nk Cells - Dr. Jekyll and Mr. Hyde in Autoimmune Rheumatic Diseases, International Immunopharmacology (2022)

8. Upregulation of Unfolded Protein Response and Er Stress–Related Il-23 Production in M1 Macrophages From Ankylosing Spondylitis Patients, Inflammation (2022)

9. New Insights Toward the Pathogenesis of Ankylosing Spondylitis; Genetic Variations and Epigenetic Modifications, Modern Rheumatology (2017)

10. Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)

11. Activation of Adenosine A2a Receptor Induced Interleukin-23 Mrna Expression in Macrophages of Ankylosing Spondylitis Patients, Cytokine (2020)

12. Ankylosing Spondylitis Monocyte-Derived Macrophages Express Increased Level of A2a Adenosine Receptor and Decreased Level of Ectonucleoside Triphosphate Diphosphohydrolase-1 (Cd39), A1 and A2b Adenosine Receptors, Clinical Rheumatology (2018)

13. Ankylosing Spondylitis M-Csf-Derived Macrophages Are Undergoing Unfolded Protein Response (Upr) and Express Higher Levels of Interleukin-23, Modern Rheumatology (2017)

14. The Association of Interleukin 6 Receptor Gene Variant (Rs4129267) With Susceptibility to Ankylosing Spondylitis and Soluble Il-6 Receptor Level in Iranian Patients, Indian Journal of Rheumatology (2025)

15. Monocyte-Derived and M1 Macrophages From Ankylosing Spondylitis Patients Released Higher Tnf-Α and Expressed More Il1b in Response to Bzatp Than Macrophages From Healthy Subjects, Scientific Reports (2021)

16. Ankylosing Spondylitis and Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach, Biomedicine and Pharmacotherapy (2019)

17. Copy Number Variation of Il17ra Gene and Its Association With the Ankylosing Spondylitis Risk in Iranian Patients: A Case-Control Study, BMC Medical Genetics (2020)

18. Oral Administration Effects of Β-D-Mannuronic Acid (M2000) on Th17 and Regulatory T Cells in Patients With Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)

19. Association Between Rs6759298 and Ankylosing Spondylitis in Iranian Population, Avicenna Journal of Medical Biotechnology (2018)

20. Immune Cells Involved in the Pathogenesis of Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)

Style	Citing Format
MLA	Babaie F, et al.. "Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis." Clinical Immunology, vol. 248, no. , 2023, pp. -.
APA	Babaie F, Mohammadi H, Salimi S, Ghanavatinegad A, Abbasifard M, Yousefi M, Hajaliloo M, Khalili Y, Zamanlou S, Safari R, Hemmatzadeh M, Rezaiemanesh A, Salimi R, Baradaran B, Babaloo Z (2023). Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis. Clinical Immunology, 248(), -.
Chicago	Babaie F, Mohammadi H, Salimi S, Ghanavatinegad A, Abbasifard M, Yousefi M, Hajaliloo M, et al.. "Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis." Clinical Immunology 248, no. (2023): -.
Harvard	Babaie F et al. (2023) 'Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis', Clinical Immunology, 248(), pp. -.
Vancouver	Babaie F, Mohammadi H, Salimi S, Ghanavatinegad A, Abbasifard M, Yousefi M, et al.. Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis. Clinical Immunology. 2023;248():-.
BibTex	@article{ author = {Babaie F and Mohammadi H and Salimi S and Ghanavatinegad A and Abbasifard M and Yousefi M and Hajaliloo M and Khalili Y and Zamanlou S and Safari R and Hemmatzadeh M and Rezaiemanesh A and Salimi R and Baradaran B and Babaloo Z}, title = {Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis}, journal = {Clinical Immunology}, volume = {248}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Babaie F AU - Mohammadi H AU - Salimi S AU - Ghanavatinegad A AU - Abbasifard M AU - Yousefi M AU - Hajaliloo M AU - Khalili Y AU - Zamanlou S AU - Safari R AU - Hemmatzadeh M AU - Rezaiemanesh A AU - Salimi R AU - Baradaran B AU - Babaloo Z TI - Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis JO - Clinical Immunology VL - 248 IS - SP - EP - PY - 2023 ER -