Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
A Study on the Concentration-Dependent Relaxometric Transition in Manganese Oxide Nanocolloid As Mri Contrast Agent Publisher



Khodaei A1 ; Malek M2 ; Hosseini HRM1 ; Delavari H H3 ; Vahdatkhah P1
Authors

Source: ChemistrySelect Published:2019


Abstract

A green precipitation method has been used for the synthesis of ultra-small APTMS-mPEG conjugated Mn3O4 nanoparticles. Spherical cores in the uniform size of 4±1 nm were characterized by HRTEM. Zeta potential of −45 mV and the invariant turbidimetry results during the time, confirmed super-stability of the colloids. MRI relaxometry by 1.5 T scanner represented two values of r1= 8.23 s−1mM−1 and r1=7.3 s−1mM−1 for diluted and concentrated samples. The r2/r1 ratio was also decreased from 11.86 to 6.9 by dilution of colloids. Particle aggregation and motional narrowing phenomena led to a dual T1/T2 contrast agent in the Mn ion concentrations of more than 0.2 mM. The optimum concentration of Mn ion for maximum dual signal intensity was estimated about 0.4 mM which is two times less than commercial Gd–DTPA. Cytotoxicity was examined through MTT assay and respectively, showed high cell viability at 48 h incubation. Overall, a potential dual T1/T2 contrast agent was developed for early-stage detection. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Related Docs
View other Related Docs
1. Monodisperse Magnetite (Fe3o4) Nanoparticles Modified With Water Soluble Polymers for the Diagnosis of Breast Cancer by Mri Method, Journal of Magnetism and Magnetic Materials (2016)
2. Tannic Acid-Mediated Synthesis of Flower-Like Mesoporous Mno2 Nanostructures As T1–T2 Dual-Modal Mri Contrast Agents and Dual-Enzyme Mimetic Agents, Scientific Reports (2023)
3. Development of Gold-Coated Magnetic Nanoparticles As a Potential Mri Contrast Agent, Nano (2015)
Experts (# of related papers)
View all Related Experts
Mehdi Khoobi (4)
Mehdi Shafee Ardestani (2)
Other Related Docs
4. Targeted Superparamagnetic Iron Oxide Nanoparticles for Early Detection of Cancer: Possibilities and Challenges, Nanomedicine: Nanotechnology# Biology# and Medicine (2016)
5. Development of Radiolabeled Dextran Coated Iron Oxide Nanoparticles With 111In and Its Biodistribution Studies, International Journal of Radiation Research (2020)
6. A New Theranostic Complex Based on Bismuth-Iron Oxide Nanoparticle for Myocardial Ischemia: In Vitro Study, Nanomedicine Research Journal (2022)
7. Development of Multifunctional Mno2-Based Nanoplatforms for Hypoxia Modulation/T1-Weighted Mri/ Optical Biosensing and Targeted Drug Delivery, Journal of Drug Delivery Science and Technology (2024)
8. Dendrimer Functionalized Magnetic Nanoparticles As a Promising Platform for Localized Hyperthermia and Magnetic Resonance Imaging Diagnosis, Journal of Cellular Physiology (2019)
9. Green Methods for the Preparation of Mgo Nanomaterials and Their Drug Delivery, Anti-Cancer and Anti-Bacterial Potentials: A Review, Inorganic Chemistry Communications (2022)
10. Theranostic Muc-1 Aptamer Targeted Gold Coated Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging and Photothermal Therapy of Colon Cancer, Colloids and Surfaces B: Biointerfaces (2016)
11. Green Synthesis and Characterization of Mnco 2 O 4 /Co 2 Mn 3 O 8 Ceramic Nanocomposites and Investigation of Their Cytotoxicity on the 4T1 Cells, Composites Part B: Engineering (2019)
12. Synthesis, Characterization and Mri Application of Cobalt-Zinc Ferrite Nanoparticles Coated With Dmsa: An In-Vivo Study, Applied Magnetic Resonance (2021)
13. The Effect of Superparamagnetic Iron Oxide Nanoparticles Surface Engineering on Relaxivity of Magnetoliposome, Contrast Media and Molecular Imaging (2016)
14. Design, Characterization and Green Synthesis of Samarium-Decorated Magnetic Fe3o4 Nanoparticles: Cytotoxicity and Dna Binding Studies, Journal of Biomolecular Structure and Dynamics (2023)
15. Syntehsis and Evaluation of Gd3+ -Trp-Plga As Novel Nanosized Mr Tumor Imaging Candidate, Nanomedicine Journal (2021)
16. Nickel-Salen Supported Paramagnetic Nanoparticles for 6-His-Target Recombinant Protein Affinity Purification, Journal of Chromatography A (2017)
17. Glutathione Conjugated Polyethylenimine on the Surface of Fe 3 O 4 Magnetic Nanoparticles As a Theranostic Agent for Targeted and Controlled Curcumin Delivery, Journal of Biomaterials Science# Polymer Edition (2018)
18. Surface Modification and Bioconjugation of Anti-Cd4 Monoclonal Antibody to Magnetic Nanoparticles As a Highly Efficient Affinity Adsorbent for Positive Selection of Peripheral Blood T Cd4+ Lymphocytes, International Journal of Biological Macromolecules (2020)
19. Superparamagnetic Iron Oxide Nanoparticles for in Vivo Molecular and Cellular Imaging, Contrast Media and Molecular Imaging (2015)
20. The Effect of Size and Aspect Ratio of Fe-Mil-88B-Nh2 Metal-Organic Frameworks on Their Relaxivity and Contrast Enhancement Properties in Mri: In Vitro and in Vivo Studies, Journal of Nanoparticle Research (2018)