Syntehsis and Evaluation of Gd3+ -Trp-Plga As Novel Nanosized Mr Tumor Imaging Candidate Publisher



Salehian E¹ ; Safa R² ; Saffari M² ; Ashrafi S³ ; Farhoudi R⁴ ; Ebrahimi SES⁵ ; Hamedani MP⁵ ; Mirzaei M⁶ ; Ardestani MS¹
Source: Nanomedicine Journal Published:2021

Abstract

Objective(s): Early detection of cancer can significantly increase the likelihood of successful treatment, and imaging assay can have a significant impact on cancer diagnosis. Although gadolinium compounds are used as a contrast agent in MRI, this substance has side effects and disadvantages. Nanotechnology has so far had a significan impact on medical imaging methods, especially MRI, nanoparticles are contrast enhancers that Each with its characteristics have increased the quality of images and reduced toxicity. Materials and Methods: In this study, a novel nano-conjugate based PLGA-tryptophan was synthesized and loaded with Gd3+ for using it as a potential MR imaging contrast agent to overcome the previous disadvantage. In vitro cell toxicity, cellular uptake and MR imaging parameters of the prepared nanoconjugate were investigated , Results: The results showed no in vivo toxicity plus flowcytometry assays, good cellular uptake and large longitudinal (r1). Conclusion: Convenient features of the nano-probe indicate that it is a promising agent to use as a MR imaging agent. © 2021 Mashhad University of Medical Sciences. All Rights Reserved.