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Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole Against a Collection of Azole-Resistant and -Susceptible Aspergillus Fumigatus Strains Publisher Pubmed



Abastabar M1 ; Rahimi N2 ; Meis JF3, 4 ; Aslani N2 ; Khodavaisy S5 ; Nabili M1 ; Rezaeimatehkolaei A6 ; Makimura K7 ; Badali H1, 8
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Source: Antimicrobial Agents and Chemotherapy Published:2016


Abstract

A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC90 values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
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