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In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators Against Dermatophyte Isolates Publisher Pubmed



Rezaeimatehkolaei A1 ; Khodavaisy S2 ; Alshahni MM3, 4 ; Tamura T3, 4 ; Satoh K3, 4 ; Abastabar M5 ; Shokoohi GR6 ; Ahmadi B7 ; Kord M2 ; Taghipour S1 ; Makimura K3, 4 ; Badalie H8
Authors

Source: Antimicrobial Agents and Chemotherapy Published:2018


Abstract

The objective of this study was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 g/ml), followed by lanoconazole (0.002 g/ml), efinaconazole (0.007 g/ml), terbinafine (0.011 g/ml), itraconazole (0.095 g/ml), and fluconazole (12.77 g/ml). It appears that efinaconazole, lanoconazole, and luliconazole are promising candidates for the treatment of dermatophytosis due to T. interdigitale and T. rubrum. Copyright © 2018 American Society for Microbiology. All Rights Reserved.
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