Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer

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Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer Publisher Pubmed

Rezaei G¹ ; Habibianbouhi M¹ ; Mahmoudi M² ; Azadmanesh K³ ; Moradikalbolandi S¹ ; Behdani M⁴ ; Ghazizadeh L¹ ; Abolhassani M⁵ ; Shokrgozar MA¹

Source: Nanomedicine Published:2017

Abstract

Aim: To develop a novel anti-CD47 single-chain variable fragment (scFv) functionalized magnetic nanoparticles (MNPs) for targeting bladder cell lines and its applicability in thermotherapy. Material & methods: An immunized murine antibody phage display library was constructed and screened to isolate anti-CD47 binders. A scFv was selected and conjugated to MNPs which was then utilized to discriminate CD47+ bladder cells along with assessing its efficacy in thermotherapy. Results: An scFv with high affinity to bladder cells was efficiently conjugated to MNPs. Following a hyperthermia treatment, the function of scFv-MNP conjugates led to a considerable reduction in cell viability. Conclusion: The anti-CD47 scFv-MNP conjugate was an effective cancer cell thermotherapy tool that might pave the way for development of bionano-based targeting techniques in both early detection and treatment of cancer. © 2017 Future Medicine Ltd.

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Style	Citing Format
MLA	Rezaei G, et al.. "Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer." Nanomedicine, vol. 12, no. 6, 2017, pp. 597-613.
APA	Rezaei G, Habibianbouhi M, Mahmoudi M, Azadmanesh K, Moradikalbolandi S, Behdani M, Ghazizadeh L, Abolhassani M, Shokrgozar MA (2017). Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer. Nanomedicine, 12(6), 597-613.
Chicago	Rezaei G, Habibianbouhi M, Mahmoudi M, Azadmanesh K, Moradikalbolandi S, Behdani M, Ghazizadeh L, Abolhassani M, Shokrgozar MA. "Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer." Nanomedicine 12, no. 6 (2017): 597-613.
Harvard	Rezaei G et al. (2017) 'Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer', Nanomedicine, 12(6), pp. 597-613.
Vancouver	Rezaei G, Habibianbouhi M, Mahmoudi M, Azadmanesh K, Moradikalbolandi S, Behdani M, et al.. Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer. Nanomedicine. 2017;12(6):597-613.
BibTex	@article{ author = {Rezaei G and Habibianbouhi M and Mahmoudi M and Azadmanesh K and Moradikalbolandi S and Behdani M and Ghazizadeh L and Abolhassani M and Shokrgozar MA}, title = {Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer}, journal = {Nanomedicine}, volume = {12}, number = {6}, pages = {597-613}, year = {2017} }
RIS	TY - JOUR AU - Rezaei G AU - Habibianbouhi M AU - Mahmoudi M AU - Azadmanesh K AU - Moradikalbolandi S AU - Behdani M AU - Ghazizadeh L AU - Abolhassani M AU - Shokrgozar MA TI - Development of Anti-Cd47 Single-Chain Variable Fragment Targeted Magnetic Nanoparticles for Treatment of Human Bladder Cancer JO - Nanomedicine VL - 12 IS - 6 SP - 597 EP - 613 PY - 2017 ER -

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