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Multi-Stimuli-Responsive Magnetic Hydrogel Based on Tragacanth Gum As a De Novo Nanosystem for Targeted Chemo/Hyperthermia Treatment of Cancer Publisher



Jahanbanesfahlan R1 ; Soleimani K2 ; Derakhshankhah H3 ; Haghshenas B4 ; Rezaei A2 ; Massoumi B5 ; Farnudiyanhabibi A6, 7 ; Samadian H2 ; Jaymand M2
Authors

Source: Journal of Materials Research Published:2021


Abstract

A novel magnetic pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was developed for targeted chemo/hyperthermia treatment of cancer. Firstly, acrylic acid (AA) monomer was grafted onto a maleic anhydride-functionalized TG macromonomer (MATGM) through a free radical copolymerization. Magnetic nanoparticles (MNPs) were synthesized through chemical co-precipitation, and subsequently were modified using (3-aminopropyl)triethoxysilane coupling agent. The magnetic stimuli-responsive hydrogel for targeted cancer therapy was synthesized by the incorporation of modified-MNPs and folic acid (FA), and simultaneous crosslinking of TG-g-PAA copolymer using cystamine (Cys) moiety. Doxorubicin hydrochloride (Dox) was loaded into the fabricated magnetic hydrogel (MH), and its release was studied under pH- and redox-triggered condition. The anti-cancer activity of the Dox-loaded DDS was examined against MCF7 cells through MTT assay by both chemotherapy and chemo/hyperthermia therapy approaches. It was revealed that the developed DDS has higher anti-cancer activity (~ 24%) owing to its “smart” and slow drug release behavior as well as synergic effect of hyperthermia therapy. Graphic abstract: A novel magnetite pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was design and developed for targeted chemo/hyperthermia therapy of solid tumors. [Figure not available: see fulltext.]. © 2021, The Author(s), under exclusive licence to The Materials Research Society.
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