Role of Exosome in Autoimmunity, With a Particular Emphasis on Rheumatoid Arthritis Publisher Pubmed



Hejrati A¹ ; Hasani B^{2, 3} ; Esmaili M^{2, 3} ; Bashash D⁴ ; Tavakolinia N⁵ ; Zafari P^{2, 3}
Source: International Journal of Rheumatic Diseases Published:2021

Abstract

Cell-derived exosomes are identified as carriers of lipids, proteins, and genetic materials that participate in cell-cell signal communication, biological process, and cell signaling. Also, their involvement has been reported in a vast array of disorders and inflammatory conditions such as autoimmune diseases. Rheumatoid arthritis (RA), a common cause of joint disorder, is an inflammation-based disease in which the precise understanding of its pathogenesis needs to be further investigated. Also, there is only a palliative care approach for the alleviation of RA symptoms. This paper discusses the recent advances in the biology of exosomes in autoimmune disorders especially in RA, and also provides a new line of research for arthritis therapy using exosomes. © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd