Immunopathology and Immunotherapy of Non-Hodgkin Lymphoma Publisher



Ebadi M¹ ; Sadeghi MA^{2, 3} ; Reddy NM⁴ ; Rezaei N^{5, 6, 7}
Source: Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors Published:2020

Abstract

Immunotherapy has been increasingly applied to the treatment of various malignancies in recent decades. Considering the limited clinical effectiveness obtained by other treatment modalities in the treatment of non-Hodgkin lymphoma (NHL), attention has been drawn to immunotherapy as an efficient alternative or complementary therapy. Importantly, the unique immunopathology of NHL makes it quite amenable to immunotherapeutic treatment. This chapter aims to discuss a broad spectrum of these approaches, ranging from monoclonal antibodies (mAbs) which were developed in the early days of immunotherapy to novel techniques developed in just the recent years. Furthermore, various applications of these agents of immunotherapy, both as monotherapy and as combinational therapy, are explored. Since a clear concept of the pathobiology of NHL is necessary for efficient immunotherapy, a brief description with an emphasis on suitable targets for immunotherapy is given before discussing various immunotherapies. © Springer Nature Switzerland AG 2020. All rights reserved.