Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises

Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises Publisher Pubmed

Miri H¹ ; Rahimzadeh P² ; Hashemi M^{3, 11, 12} ; Nabavi N⁵ ; Aref AR⁶ ; Daneshi S⁷ ; Razzaghi A⁸ ; Abedi M⁹ ; Tahmasebi S¹⁰ ; Farahani N^{3, 11, 12} ; Taheriazam A^{3, 11, 12}

Source: Pathology, research and practice Published:2025

Abstract

HCC is considered as one of the leadin causes of death worldwide, with the ability of resistance towards therapeutics. Immunotherapy, particularly ICIs, have provided siginficant insights towards harnessing the immune system. The present review introduces the concepts and possibilities of immunotherapy for HCC treatment, emphasizing its underlying mechanisms and capacity to enhance patient results, focusing on both pre-clinical and clinical insights. The functions of TME and immune evasion mechanisms typical of HCC would be evaluated along with how contemporary immunotherapeutic approaches are designed to address these challenges. Furthermore, the clinical application of immunotherapy in HCC is discussed, emphasizing recent trial findings demonstrating the effectiveness and safety of drugs. In addition, the problems caused by immune evasion and resistance would be discussed to increase potential of immunotherapy along with combination therapy. Copyright © 2025 Elsevier GmbH. All rights reserved.

Style	Citing Format
MLA	Miri H, et al.. "Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises." Pathology, research and practice, vol. 269, no. , 2025, pp. 155928-.
APA	Miri H, Rahimzadeh P, Hashemi M, Nabavi N, Aref AR, Daneshi S, Razzaghi A, Abedi M, Tahmasebi S, Farahani N, Taheriazam A (2025). Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises. Pathology, research and practice, 269(), 155928-.
Chicago	Miri H, Rahimzadeh P, Hashemi M, Nabavi N, Aref AR, Daneshi S, Razzaghi A, et al.. "Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises." Pathology, research and practice 269, no. (2025): 155928-.
Harvard	Miri H et al. (2025) 'Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises', Pathology, research and practice, 269(), pp. 155928-.
Vancouver	Miri H, Rahimzadeh P, Hashemi M, Nabavi N, Aref AR, Daneshi S, et al.. Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises. Pathology, research and practice. 2025;269():155928-.
BibTex	@article{ author = {Miri H and Rahimzadeh P and Hashemi M and Nabavi N and Aref AR and Daneshi S and Razzaghi A and Abedi M and Tahmasebi S and Farahani N and Taheriazam A}, title = {Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises}, journal = {Pathology, research and practice}, volume = {269}, number = {}, pages = {155928-}, year = {2025} }
RIS	TY - JOUR AU - Miri H AU - Rahimzadeh P AU - Hashemi M AU - Nabavi N AU - Aref AR AU - Daneshi S AU - Razzaghi A AU - Abedi M AU - Tahmasebi S AU - Farahani N AU - Taheriazam A TI - Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises JO - Pathology, research and practice VL - 269 IS - SP - 155928 EP - PY - 2025 ER -

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