Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence Publisher Pubmed



Nili M1 ; Tayeri K2 ; Gholami M1 ; Moallemi S2 ; Sabahi F1 ; Kalhori S4 ; Baesi K3 ; Hasibi M2
Authors

Source: Infectious Disorders - Drug Targets Published:2019


Abstract

Background: The rate of human immunodeficiency virus type 1 (HIV-1) infection in Iran has increased dramatically in the past few years. HIV-1 genome sequences are pivotal for large-scale studies of inter-and intra-host evolution. To understand the molecular difference between reference HIV-1 isolate and two HIV-1 infected patients in Iran, we conducted this study to analyze some genome segments of Iranian HIV-1 isolates. Methods: Two HIV-1-infected individuals who were under antiretroviral therapy (ARV) for 8 years with stable clinical status were enrolled. The patient’s plasma samples were used for the Gag-Pol genome sequences (4500 nt). The phylogenetic tree and similarity plotty were obtained based on Gag-Pol sequences. Results: Both HIV-1-infected isolates belonged to CRF35_AD subtype even though one of them had drug resistance. The HIV genome and protein sequences showed no clear difference between genome and protein sequences of our samples and the reference sequence. Conclusions:whichOurcouldpatient’sbe owingstableto clinicalimmunologicalstatus hadfactorsno connectionor other patient’sto genomemodese-quence; which are still unknown. © 2019 Bentham Science Publishers.
Other Related Docs
6. Hiv Drug Resistance Among Naive Hiv-Infected Patients in Iran, Journal of Research in Medical Sciences (2019)
18. Epidemiology of Hiv in Iran, Current HIV Research (2020)