Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals Publisher



Khanaliha K1 ; Bokharaeisalim F2 ; Donyavi T3 ; Nahand JS4 ; Marjani A5 ; Jamshidi S2 ; Khatami A2 ; Moghaddas M6 ; Esghaei M2 ; Fakhim A7
Authors

Source: Future Virology Published:2022


Abstract

Aim: This study aimed to evaluate chemokine receptor 5 delta 32 (CCR5-δ32) mutation and HIV-1 surveillance drug-resistance mutations (SDRMs) in peripheral blood mononuclear cells of long-term non progressors (LTNPs) of HIV-1-infected individuals. Materials & methods: This research was performed on 197 treatment-naive HIV-1-infected patients. After follow-up, it was determined that 15 (7.6%) of these people were LTNPs. The PCR assay was performed to identify the CCR5 genotype and HIV-1 SDRMs. Results: One (6.7%) of the LTNPs was heterozygous (wt/δ32) for the CCR5 delta 32 (CCR5δ32). However, none of the individuals was homozygous for this mutation (δ32/δ32). Moreover, none of the LTNPs showed HIV-1 SDRMs. The CRF35-AD subtype was the most dominant subtype, with a percentage of 93.3%. Conclusion: Iranian elite controllers are negative for CCR5-delta 32 homozygous genotype and drug resistance against antiretroviral drugs. © 2022 Future Medicine Ltd.
Other Related Docs
18. The Effect of Intravenous Heroin Injection on Gene Expression in Hiv-1 Infected People, Heroin Addiction and Related Clinical Problems (2024)