Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study Publisher Pubmed



Nobakht BF^{1, 2} ; Aliannejad R³ ; Rezaeitavirani M¹ ; Arefi Oskouie A² ; Naseri MT⁴ ; Parastar H⁵ ; Aliakbarzadeh G⁶ ; Fathi F⁵ ; Taheri S⁷
Source: Biomarkers Published:2016

Abstract

Sulfur mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and healthy controls are observed are related to lipid metabolism, ketogenesis, tricarboxylic acid (TCA) cycle and amino acid metabolism. © 2016 Informa UK Limited, trading as Taylor & Francis Group.