Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Nmr Spectroscopy-Based Metabolomic Study of Serum in Sulfur Mustard Exposed Patients With Lung Disease Publisher Pubmed



Arefi Oskouie A2 ; Rezaeitavirani M1 ; Aliannejad R3 ; Taheri S4 ; Fathi F5 ; Taghi Naseri M6
Authors

Source: Biomarkers Published:2017


Abstract

Sulfur mustard (SM) is a vesication chemical warfare agent for which there is currently no antidote. Despite years of research, there is no common consensus about the pathophysiological basis of chronic pulmonary disease caused by this chemical warfare agent. In this study, we combined chemometric techniques with nuclear magnetic resonance (NMR) spectroscopy to explore the metabolic profile of sera from SM-exposed patients. A total of 29 serum samples obtained from 17 SM-injured patients, and 12 healthy controls were analyzed by Random Forest. Increased concentrations of seven amino acids, glycerol, dimethylamine, ketone bodies, lactate, acetate, citrulline and creatine together with the decreased very low-density lipoproteins (VLDL) levels were observed in patients compared with control subjects. Our study reveals the metabolic profile of sera from SM-injured patients and indicates that NMR-based methods can distinguish these patients from healthy controls. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study, Biomarkers (2016)
2. Metabolomics Diagnostic Approach to Mustard Airway Diseases: A Preliminary Study, Iranian Journal of Basic Medical Sciences (2018)
3. Nuclear Magnetic Resonance -Based Metabolomics Analysis of Patients Exposed to Sulfur Mustard in Different Stages Using Random Forest Method, Koomesh (2016)
Experts (# of related papers)
View all Related Experts
Rasoul Aliannejad (5)
Reza Malekzadeh (1)
Other Related Docs
4. Pro-Oxidant–Antioxidant Balance in Iranian Veterans With Sulfur Mustard Toxicity and Different Levels of Pulmonary Disorders, Drug and Chemical Toxicology (2016)
5. Characterization of Lung Fibroblasts More Than Two Decades After Mustard Gas Exposure, PLoS ONE (2015)
6. Metabolomics Analysis of the Saliva in Patients With Chronic Hepatitis B Using Nuclear Magnetic Resonance: A Pilot Study, Iranian Journal of Basic Medical Sciences (2019)
7. The Predictive Association Between Radiological Findings and Lung Cancer Development in Patients Exposed to Sulfur Mustard Gas: 4 Decades Follow up of 719 Victims, BMC Pulmonary Medicine (2022)
8. Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment, Acta Medica Iranica (2016)
9. Circulating Mesenchymal Stem Cells in Sulfur Mustard-Exposed Patients With Long-Term Pulmonary Complications, Toxicology Letters (2019)
10. Th17/Treg Immunoregulation and Implications in Treatment of Sulfur Mustard Gas-Induced Lung Diseases, Expert Review of Clinical Immunology (2017)
11. The Footprint of Tgf-Β in Airway Remodeling of the Mustard Lung, Inhalation Toxicology (2015)
12. The Metabolome Profiling of Obese and Non-Obese Individuals: Metabolically Healthy Obese and Unhealthy Non-Obese Paradox, Iranian Journal of Basic Medical Sciences (2020)
13. Paraclinical Findings in Iranian Veterans Exposed to Sulfur Mustard Gas: A Literature Review, Chinese Journal of Traumatology - English Edition (2017)
14. Health Problems in Survivors Exposed to Sulfur Mustard With Severe Respiratory Complications, Iranian Journal of War and Public Health (2021)
15. Pulmonary Rehabilitation in Iranian Outpatients With Mustard Gas Lung Disease: A Randomised Controlled Trial, BMJ Open (2024)
16. Immunology of Chronic Obstructive Pulmonary Disease and Sulfur Mustard Induced Airway Injuries: Implications for Immunotherapeutic Interventions, Current Pharmaceutical Design (2016)
17. Staging of Colorectal Cancer Using Serum Metabolomics With1hnmr Spectroscopy, Iranian Journal of Basic Medical Sciences (2017)
18. The Metabolomics of Airway Diseases, Including Copd, Asthma and Cystic Fibrosis, Biomarkers (2015)
19. Plasma Metabolites Analysis of Patients With Papillary Thyroid Cancer: A Preliminary Untargeted 1H Nmr-Based Metabolomics, Journal of Pharmaceutical and Biomedical Analysis (2024)
20. Investigating the Role of Uric Acid and Uric Acid-To-Creatinine Ratio As a Predictive Factor of Chronic Obstructive Pulmonary Disease Exacerbation in 2019, Clinical Respiratory Journal (2023)