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Effects of Olive Leaf Extract on Myoclonic and Tonico-Clonic Seizures in Mice Publisher



Shahabi R1 ; Ramezani F2 ; Nasirinezhad F3 ; Shahabi B4 ; Rostampour M5
Authors

Source: Neurophysiology Published:2018


Abstract

Effects of a hydroalcoholic olive leaf extract (OLE) on pentylenetetrazol (PTZ, 80 mg/kg)-induced seizures in mice were examined. As was found, the OLE significantly increased the delay of PTZinitiated myoclonic seizures when injected i.p. in a dose of 1000 mg/kg and also significantly delayed the initiation of tonico-clonic seizures in doses from 250 to 1000 mg/kg. The effects of the OLE on clonico-tonic seizures were more intense than those on myoclonic seizures. The OLE also significantly reduced the mortality rate within a 24-h observation period after PTZ injections. At 125 and 1000 mg/kg doses, 2 and 7 animals of 8 individuals in the OLE-treated groups survived, while all 8 mice died during 24 h in the control group. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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