Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Anticonvulsant Effects of Aerial Parts of Verbena Officinalis Extract in Mice: Involvement of Benzodiazepine and Opioid Receptors Publisher



Rashidian A1 ; Kazemi F2 ; Mehrzadi S3 ; Dehpour AR1 ; Mehr SE1 ; Rezayat SM1, 2
Authors

Source: Journal of Evidence-Based Complementary and Alternative Medicine Published:2017


Abstract

To evaluate the anticonvulsant activity of the aerial parts of Verbena officinalis used traditionally by local Iranians for the treatment of convulsion. The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizures in mice. Diazepam was used as reference drug. In addition, for investigating the mechanism of V officinalis in PTZ model, flumazenil and naloxone were injected before V officinalis. The extract showed no toxicity and significantly increased the period taken before the onset and decreased the duration of the seizures induced by PTZ. In the MES test, V officinalis displayed significant reduction in hind limb tonic extension duration in a dose-dependent manner. The results propose that V officinalis ethanolic extract has anticonvulsant activity against seizure. It seems that these effects may be related to potentiating of GABAergic system. Moreover, this study supports the use of this plant by local Iranians in order to treat convulsion. © 2017, © The Author(s) 2017.
Related Docs
View other Related Docs
1. Anticonvulsant Effects of Lippia Citriodora (Verbenaceae) Leaves Ethanolic Extract in Mice: Role of Gabaergic System, International Journal of Preventive Medicine (2016)
2. Anticonvulsant Effect of Alcea Aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice, Basic and Clinical Neuroscience (2020)
3. The Role of Opioid and Nitrergic Systems in Dual Modulation of Seizure Susceptibility, Advancements in Life Sciences (2020)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (15)
Massoud Amanlou (4)
Other Related Docs
4. Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria Majdae (Rech.) in Mice: The Role of Gabaa Neurotransmission and the Nitric Oxide Pathway, Clinical and Translational Science (2020)
5. Effects of Onopordia, a Novel Isolated Compound From Onopordon Acanthium, on Pentylenetetrazole-Induced Seizures in Mice: Possible Involvement of Nitric Oxide Pathway, Journal of Traditional and Complementary Medicine (2021)
6. Sumatriptan Reduces Severity of Status Epilepticus Induced by Lithium–Pilocarpine Through Nitrergic Transmission and 5-Ht1b/D Receptors in Rats: A Pharmacological-Based Evidence, Fundamental and Clinical Pharmacology (2021)
7. Pharmacological Evidence for the Possible Involvement of the Nmda Receptor Pathway in the Anticonvulsant Effect of Tramadol in Mice, AIMS Neuroscience (2022)
8. Novel Fused 1,2,3-Triazolo-Benzodiazepine Derivatives As Potent Anticonvulsant Agents: Design, Synthesis, in Vivo, and in Silico Evaluations, Molecular Diversity (2020)
9. Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice, Acta Medica Iranica (2018)
10. Anticonvulsant Effects of Ivermectin on Pentylenetetrazole- and Maximal Electroshock-Induced Seizures in Mice: The Role of Gabaergic System and Katp Channels, Heliyon (2022)
11. Novel Effect of Arthrocen (Avocado/Soy Unsaponifiables) on Pentylenetetrazole-Induced Seizure Threshold in Mice: Role of Gabaergic Pathway, Epilepsy and Behavior (2020)
12. Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies, Journal of Biochemical and Molecular Toxicology (2023)
13. Modulatory Effect of Opioid Ligands on Status Epilepticus and the Role of Nitric Oxide Pathway, Epilepsy and Behavior (2019)
14. Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway, Pharmaceutical Sciences (2018)
15. The Possible Role of Nitric Oxide in Anti-Convulsant Effects of Naltrindole in Seizure-Induced by Social Isolation Stress in Male Mice, Biomedicine and Pharmacotherapy (2020)
16. Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2015)
17. Synthesis, in Vivo and in Silico Studies of N-Aryl-4-(1,3-Dioxoisoindolin-2-Yl)Benzamides As an Anticonvulsant Agent, Pharmaceutical Sciences (2020)
18. Possible Involvement of Nitrergic and Opioidergic Systems in the Modulatory Effect of Acute Chloroquine Treatment on Pentylenetetrazol Induced Convulsions in Mice, Brain Research Bulletin (2016)
19. Acute Foot-Shock Stress Decreased Seizure Susceptibility Against Pentylenetetrazole-Induced Seizures in Mice: Interaction Between Endogenous Opioids and Cannabinoids, Epilepsy and Behavior (2018)
20. Design, Synthesis, Anticonvulsant Evaluation, and Molecular Docking Studies of New Gabaa Agonist Derivatives, Iranian Journal of Pharmaceutical Research (2025)