Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax

Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax Publisher Pubmed

Kanis JA^{1, 2} ; Johansson H^{1, 3} ; Mccloskey EV^{2, 4} ; Liu E¹ ; Akesson KE^{5, 6} ; Anderson FA⁷ ; Azagra R^{8, 9, 10} ; Bager CL¹¹ ; Beaudart C^{12, 13} ; Bischoffferrari HA^{14, 15} ; Biver E¹⁶ ; Bruyere O¹² ; Cauley JA¹⁷ ; Center JR^{18, 19, 20} Show All Authors

Kanis JA^{1, 2}
Johansson H^{1, 3}
Mccloskey EV^{2, 4}
Liu E¹
Akesson KE^{5, 6}
Anderson FA⁷
Azagra R^{8, 9, 10}
Bager CL¹¹
Beaudart C^{12, 13}
Bischoffferrari HA^{14, 15}
Biver E¹⁶
Bruyere O¹²
Cauley JA¹⁷
Center JR^{18, 19, 20}
Chapurlat R²¹
Christiansen C¹¹
Cooper C^{22, 23, 24}
Crandall CJ²⁵
Cummings SR²⁶
Da Silva JAP^{27, 28}
Dawsonhughes B²⁹
Diezperez A³⁰
Dufour AB^{31, 32}
Eisman JA^{18, 19, 20}
Elders PJM³³
Ferrari S¹⁶
Fujita Y³⁴
Fujiwara S³⁵
Gluer CC³⁶
Goldshtein I^{37, 38}
Goltzman D³⁹
Gudnason V^{40, 41}
Hall J⁴²
Hans D⁴³
Hoff M^{44, 45}
Hollick RJ⁴⁶
Huisman M^{47, 48}
Iki M⁴⁹
Ishshalom S⁵⁰
Jones G⁵¹
Karlsson MK^{5, 6}
Khosla S⁵²
Kiel DP^{31, 32}
Koh WP^{53, 54}
Koromani F^{55, 56}
Kotowicz MA^{57, 58, 59}
Kroger H^{60, 61}
Kwok T^{62, 63}
Lamy O^{64, 65}
Langhammer A⁶⁶
Larijani B⁶⁷
Lippuner K⁶⁸
Mellstrom D^{69, 70}
Merlijn T⁷¹
Nordstrom A^{72, 73, 74}
Nordstrom P⁷⁵
Oneill TW^{76, 77}
Obermayerpietsch B^{78, 79}
Ohlsson C^{80, 81}
Orwoll ES⁸²
Pasco JA^{57, 58, 59, 83}
Rivadeneira F⁵⁵
Schott AM⁸⁴
Shiroma EJ⁸⁵
Siggeirsdottir K^{40, 86}
Simonsick EM⁸⁷
Sornayrendu E⁸⁸
Sund R⁶¹
Swart KMA^{33, 89}
Szulc P⁸⁸
Tamaki J⁹⁰
Torgerson DJ⁹¹
Van Schoor NM⁴⁷
Van Staa TP⁹²
Vila J⁹³
Wareham NJ⁹⁴
Wright NC⁹⁵
Yoshimura N⁹⁶
Zillikens MC⁵⁵
Zwart M^{10, 97, 98, 99}
Vandenput L^{1, 80}
Harvey NC^{22, 23}
Lorentzon M^{1, 3}
Leslie WD¹⁰⁰

Source: Osteoporosis International Published:2023

Abstract

Summary: A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX. Introduction: The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD). Methods: We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Covariates examined were age, sex, BMD, and duration of follow-up. The results of the different studies were merged by using the weighted β-coefficients. Results: A previous fracture history, compared with individuals without a prior fracture, was associated with a significantly increased risk of any clinical fracture (hazard ratio, HR = 1.88; 95% CI = 1.72–2.07). The risk ratio was similar for the outcome of osteoporotic fracture (HR = 1.87; 95% CI = 1.69–2.07), major osteoporotic fracture (HR = 1.83; 95% CI = 1.63–2.06), or for hip fracture (HR = 1.82; 95% CI = 1.62–2.06). There was no significant difference in risk ratio between men and women. Subsequent fracture risk was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any clinical fracture (14%), osteoporotic fracture (17%), and for hip fracture (33%). The risk ratio for all fracture outcomes related to prior fracture decreased significantly with adjustment for age and time since baseline examination. Conclusion: A previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by BMD. The effect is similar in men and women. Its quantitation on an international basis permits the more accurate use of this risk factor in case finding strategies. © 2023, International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.

Related Docs

View other Related Docs

1. Update of the Fracture Risk Prediction Tool Frax: A Systematic Review of Potential Cohorts and Analysis Plan, Osteoporosis International (2022)

2. A Meta-Analysis of Previous Falls and Subsequent Fracture Risk in Cohort Studies, Osteoporosis International (2024)

3. Designing an Iran Frax Model and Defining Intervention and Assessment Thresholds for Osteoporosis, Iranian Journal of Epidemiology (2021)

Experts (# of related papers)

View all Related Experts

Bagher Larijani (11)

Afshin Ostovar (8)

Style	Citing Format
MLA	Kanis JA, et al.. "Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax." Osteoporosis International, vol. 34, no. 12, 2023, pp. 2027-2045.
APA	Kanis JA, Johansson H, Mccloskey EV, Liu E, Akesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoffferrari HA, Biver E, Bruyere O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, ... Leslie WD (2023). Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax. Osteoporosis International, 34(12), 2027-2045.
Chicago	Kanis JA, Johansson H, Mccloskey EV, Liu E, Akesson KE, Anderson FA, Azagra R, et al.. "Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax." Osteoporosis International 34, no. 12 (2023): 2027-2045.
Harvard	Kanis JA et al. (2023) 'Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax', Osteoporosis International, 34(12), pp. 2027-2045.
Vancouver	Kanis JA, Johansson H, Mccloskey EV, Liu E, Akesson KE, Anderson FA, et al.. Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax. Osteoporosis International. 2023;34(12):2027-2045.
BibTex	@article{ author = {Kanis JA and Johansson H and Mccloskey EV and Liu E and Akesson KE and Anderson FA and Azagra R and Bager CL and Beaudart C and Bischoffferrari HA and Biver E and Bruyere O and Cauley JA and Center JR and Chapurlat R and Christiansen C and Cooper C and Crandall CJ and Cummings SR and Da Silva JAP and Dawsonhughes B and Diezperez A and Dufour AB and Eisman JA and Elders PJM and Ferrari S and Fujita Y and Fujiwara S and Gluer CC and Goldshtein I and Goltzman D and Gudnason V and Hall J and Hans D and Hoff M and Hollick RJ and Huisman M and Iki M and Ishshalom S and Jones G and Karlsson MK and Khosla S and Kiel DP and Koh WP and Koromani F and Kotowicz MA and Kroger H and Kwok T and Lamy O and Langhammer A and Larijani B and Lippuner K and Mellstrom D and Merlijn T and Nordstrom A and Nordstrom P and Oneill TW and Obermayerpietsch B and Ohlsson C and Orwoll ES and Pasco JA and Rivadeneira F and Schott AM and Shiroma EJ and Siggeirsdottir K and Simonsick EM and Sornayrendu E and Sund R and Swart KMA and Szulc P and Tamaki J and Torgerson DJ and Van Schoor NM and Van Staa TP and Vila J and Wareham NJ and Wright NC and Yoshimura N and Zillikens MC and Zwart M and Vandenput L and Harvey NC and Lorentzon M and Leslie WD}, title = {Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax}, journal = {Osteoporosis International}, volume = {34}, number = {12}, pages = {2027-2045}, year = {2023} }
RIS	TY - JOUR AU - Kanis JA AU - Johansson H AU - Mccloskey EV AU - Liu E AU - Akesson KE AU - Anderson FA AU - Azagra R AU - Bager CL AU - Beaudart C AU - Bischoffferrari HA AU - Biver E AU - Bruyere O AU - Cauley JA AU - Center JR AU - Chapurlat R AU - Christiansen C AU - Cooper C AU - Crandall CJ AU - Cummings SR AU - Da Silva JAP AU - Dawsonhughes B AU - Diezperez A AU - Dufour AB AU - Eisman JA AU - Elders PJM AU - Ferrari S AU - Fujita Y AU - Fujiwara S AU - Gluer CC AU - Goldshtein I AU - Goltzman D AU - Gudnason V AU - Hall J AU - Hans D AU - Hoff M AU - Hollick RJ AU - Huisman M AU - Iki M AU - Ishshalom S AU - Jones G AU - Karlsson MK AU - Khosla S AU - Kiel DP AU - Koh WP AU - Koromani F AU - Kotowicz MA AU - Kroger H AU - Kwok T AU - Lamy O AU - Langhammer A AU - Larijani B AU - Lippuner K AU - Mellstrom D AU - Merlijn T AU - Nordstrom A AU - Nordstrom P AU - Oneill TW AU - Obermayerpietsch B AU - Ohlsson C AU - Orwoll ES AU - Pasco JA AU - Rivadeneira F AU - Schott AM AU - Shiroma EJ AU - Siggeirsdottir K AU - Simonsick EM AU - Sornayrendu E AU - Sund R AU - Swart KMA AU - Szulc P AU - Tamaki J AU - Torgerson DJ AU - Van Schoor NM AU - Van Staa TP AU - Vila J AU - Wareham NJ AU - Wright NC AU - Yoshimura N AU - Zillikens MC AU - Zwart M AU - Vandenput L AU - Harvey NC AU - Lorentzon M AU - Leslie WD TI - Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax JO - Osteoporosis International VL - 34 IS - 12 SP - 2027 EP - 2045 PY - 2023 ER -

Style

Citing Format

MLA

Kanis JA, et al.. "Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax." Osteoporosis International, vol. 34, no. 12, 2023, pp. 2027-2045.

APA

Kanis JA, Johansson H, Mccloskey EV, Liu E, Akesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoffferrari HA, Biver E, Bruyere O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, ... Leslie WD (2023). Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax. Osteoporosis International, 34(12), 2027-2045.

Chicago

Kanis JA, Johansson H, Mccloskey EV, Liu E, Akesson KE, Anderson FA, Azagra R, et al.. "Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax." Osteoporosis International 34, no. 12 (2023): 2027-2045.

Harvard

Kanis JA et al. (2023) 'Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax', Osteoporosis International, 34(12), pp. 2027-2045.

Vancouver

Kanis JA, Johansson H, Mccloskey EV, Liu E, Akesson KE, Anderson FA, et al.. Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax. Osteoporosis International. 2023;34(12):2027-2045.

BibTex

@article{ author = {Kanis JA and Johansson H and Mccloskey EV and Liu E and Akesson KE and Anderson FA and Azagra R and Bager CL and Beaudart C and Bischoffferrari HA and Biver E and Bruyere O and Cauley JA and Center JR and Chapurlat R and Christiansen C and Cooper C and Crandall CJ and Cummings SR and Da Silva JAP and Dawsonhughes B and Diezperez A and Dufour AB and Eisman JA and Elders PJM and Ferrari S and Fujita Y and Fujiwara S and Gluer CC and Goldshtein I and Goltzman D and Gudnason V and Hall J and Hans D and Hoff M and Hollick RJ and Huisman M and Iki M and Ishshalom S and Jones G and Karlsson MK and Khosla S and Kiel DP and Koh WP and Koromani F and Kotowicz MA and Kroger H and Kwok T and Lamy O and Langhammer A and Larijani B and Lippuner K and Mellstrom D and Merlijn T and Nordstrom A and Nordstrom P and Oneill TW and Obermayerpietsch B and Ohlsson C and Orwoll ES and Pasco JA and Rivadeneira F and Schott AM and Shiroma EJ and Siggeirsdottir K and Simonsick EM and Sornayrendu E and Sund R and Swart KMA and Szulc P and Tamaki J and Torgerson DJ and Van Schoor NM and Van Staa TP and Vila J and Wareham NJ and Wright NC and Yoshimura N and Zillikens MC and Zwart M and Vandenput L and Harvey NC and Lorentzon M and Leslie WD}, title = {Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax}, journal = {Osteoporosis International}, volume = {34}, number = {12}, pages = {2027-2045}, year = {2023} }

RIS

TY - JOUR
AU - Kanis JA
AU - Johansson H
AU - Mccloskey EV
AU - Liu E
AU - Akesson KE
AU - Anderson FA
AU - Azagra R
AU - Bager CL
AU - Beaudart C
AU - Bischoffferrari HA
AU - Biver E
AU - Bruyere O
AU - Cauley JA
AU - Center JR
AU - Chapurlat R
AU - Christiansen C
AU - Cooper C
AU - Crandall CJ
AU - Cummings SR
AU - Da Silva JAP
AU - Dawsonhughes B
AU - Diezperez A
AU - Dufour AB
AU - Eisman JA
AU - Elders PJM
AU - Ferrari S
AU - Fujita Y
AU - Fujiwara S
AU - Gluer CC
AU - Goldshtein I
AU - Goltzman D
AU - Gudnason V
AU - Hall J
AU - Hans D
AU - Hoff M
AU - Hollick RJ
AU - Huisman M
AU - Iki M
AU - Ishshalom S
AU - Jones G
AU - Karlsson MK
AU - Khosla S
AU - Kiel DP
AU - Koh WP
AU - Koromani F
AU - Kotowicz MA
AU - Kroger H
AU - Kwok T
AU - Lamy O
AU - Langhammer A
AU - Larijani B
AU - Lippuner K
AU - Mellstrom D
AU - Merlijn T
AU - Nordstrom A
AU - Nordstrom P
AU - Oneill TW
AU - Obermayerpietsch B
AU - Ohlsson C
AU - Orwoll ES
AU - Pasco JA
AU - Rivadeneira F
AU - Schott AM
AU - Shiroma EJ
AU - Siggeirsdottir K
AU - Simonsick EM
AU - Sornayrendu E
AU - Sund R
AU - Swart KMA
AU - Szulc P
AU - Tamaki J
AU - Torgerson DJ
AU - Van Schoor NM
AU - Van Staa TP
AU - Vila J
AU - Wareham NJ
AU - Wright NC
AU - Yoshimura N
AU - Zillikens MC
AU - Zwart M
AU - Vandenput L
AU - Harvey NC
AU - Lorentzon M
AU - Leslie WD
TI - Previous Fracture and Subsequent Fracture Risk: A Meta-Analysis to Update Frax
JO - Osteoporosis International
VL - 34
IS - 12
SP - 2027
EP - 2045
PY - 2023
ER -

Science Communicator Platform

Authors

Abstract