Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019

Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019 Publisher Pubmed

Wu AM¹ ; Bisignano C² ; James SL⁶ ; Abady GG⁷ ; Abedi A⁸ ; Abugharbieh E⁹ ; Alhassan RK¹⁰ ; Alipour V^{11, 12} ; Arabloo J¹¹ ; Asaad M¹⁵ ; Asmare WN¹⁶ ; Awedew AF¹⁷ ; Banach M^{18, 19} ; Banerjee SK²⁰ Show All Authors

Wu AM¹
Bisignano C²
James SL⁶
Abady GG⁷
Abedi A⁸
Abugharbieh E⁹
Alhassan RK¹⁰
Alipour V^{11, 12}
Arabloo J¹¹
Asaad M¹⁵
Asmare WN¹⁶
Awedew AF¹⁷
Banach M^{18, 19}
Banerjee SK²⁰
Bijani A²¹
Birhanu TTM²²
Bolla SR²³
Camera LA^{24, 25}
Chang JC^{27, 28}
Cho DY³
Chung MY²⁹
Couto RAS³⁰
Dai X²
Dandona L^{2, 32, 33}
Dandona R^{2, 4, 32}
Farzadfar F³⁴
Filip I^{36, 37}
Fischer F³⁸
Fomenkov AA³⁹
Gill TK⁴⁰
Gupta B⁴¹
Haagsma JA⁴²
Hajmirzaian A^{35, 43}
Hamidi S⁴⁴
Hay SI^{2, 4}
Ilic IM⁴⁵
Ilic MD⁴⁶
Ivers RQ⁴⁷
Jurisson M⁴⁸
Kalhor R^{49, 50}
Kanchan T⁵¹
Kavetskyy T^{52, 53}
Khalilov R^{54, 55}
Khan EA⁵⁶
Khan M⁵⁷
Kneib CJ³
Krishnamoorthy V^{5, 58}
Kumar GA³²
Kumar N⁵⁹
Lalloo R⁶⁰
Lasrado S⁶¹
Lim SS^{2, 4}
Liu Z²
Manafi A¹³
Manafi N^{14, 62}
Menezes RG⁶³
Meretoja TJ^{64, 65}
Miazgowski B^{66, 67}
Miller TR^{68, 69}
Mohammad Y⁷⁰
Mohammadianhafshejani A⁷¹
Mokdad AH^{2, 4}
Murray CJL^{2, 4}
Naderi M⁷²
Naimzada MD^{74, 75}
Nayak VC⁷⁶
Nguyen CT⁷⁸
Nikbakhsh R⁴³
Olagunju AT^{79, 80}
Otstavnov N⁷⁴
Otstavnov SS^{74, 81}
Padubidri JR⁷⁷
Pereira J⁸²
Pham HQ⁷⁸
Pinheiro M³¹
Polinder S⁴²
Pourchamani H⁷³
Rabiee N⁸³
Radfar A⁸⁴
Ur Rahman MH⁸⁵
Rawaf DL^{86, 88}
Rawaf S^{87, 89}
Saeb MR⁹⁰
Samy AM⁹¹
Riera LS^{92, 93}
Schwebel DC⁹⁴
Shahabi S⁹⁵
Shaikh MA⁹⁶
Soheili A⁹⁷
Tabaresseisdedos R^{98, 99}
Tovanipalone MR^{100, 101}
Tran BX¹⁰²
Travillian RS²
Valdez PR^{26, 103}
Vasankari TJ¹⁰⁴
Velazquez DZ¹⁰⁵
Venketasubramanian N^{106, 107}
Vu GT¹⁰⁸
Zhang ZJ¹⁰⁹
Vos T^{2, 4}

Source: The Lancet Healthy Longevity Published:2021

Abstract

Background: Bone fractures are a global public health issue; however, to date, no comprehensive study of their incidence and burden has been done. We aimed to measure the global, regional, and national incidence, prevalence, and years lived with disability (YLDs) of fractures from 1990 to 2019. Methods: Using the framework of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we compared numbers and age-standardised rates of global incidence, prevalence, and YLDs of fractures across the 21 GBD regions and 204 countries and territories, by age, sex, and year, from 1990 to 2019. We report estimates with 95% uncertainty intervals (UIs). Findings: Globally, in 2019, there were 178 million (95% UI 162–196) new fractures (an increase of 33·4% [30·1–37·0] since 1990), 455 million (428–484) prevalent cases of acute or long-term symptoms of a fracture (an increase of 70·1% [67·5–72·5] since 1990), and 25·8 million (17·8–35·8) YLDs (an increase of 65·3% [62·4–68·0] since 1990). The age-standardised rates of fractures in 2019 were 2296·2 incident cases (2091·1–2529·5) per 100 000 population (a decrease of 9·6% [8·1–11·1] since 1990), 5614·3 prevalent cases (5286·1–5977·5) per 100 000 population (a decrease of 6·7% [5·7–7·6] since 1990), and 319·0 YLDs (220·1–442·5) per 100 000 population (a decrease of 8·4% [7·2–9·5] since 1990). Lower leg fractures of the patella, tibia or fibula, or ankle were the most common and burdensome fracture in 2019, with an age-standardised incidence rate of 419·9 cases (345·8–512·0) per 100 000 population and an age-standardised rate of YLDs of 190·4 (125·0–276·9) per 100 000 population. In 2019, age-specific rates of fracture incidence were highest in the oldest age groups, with, for instance, 15 381·5 incident cases (11 245·3–20 651·9) per 100 000 population in those aged 95 years and older. Interpretation: The global age-standardised rates of incidence, prevalence, and YLDs for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially. Older people have a particularly high risk of fractures, and more widespread injury-prevention efforts and access to screening and treatment of osteoporosis for older individuals should help to reduce the overall burden. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

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Style	Citing Format
MLA	Wu AM, et al.. "Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019." The Lancet Healthy Longevity, vol. 2, no. 9, 2021, pp. e580-e592.
APA	Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abugharbieh E, Alhassan RK, Alipour V, Arabloo J, Asaad M, Asmare WN, Awedew AF, Banach M, Banerjee SK, Bijani A, Birhanu TTM, Bolla SR, Camera LA, Chang JC, ... Vos T (2021). Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019. The Lancet Healthy Longevity, 2(9), e580-e592.
Chicago	Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abugharbieh E, Alhassan RK, et al.. "Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019." The Lancet Healthy Longevity 2, no. 9 (2021): e580-e592.
Harvard	Wu AM et al. (2021) 'Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019', The Lancet Healthy Longevity, 2(9), pp. e580-e592.
Vancouver	Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abugharbieh E, et al.. Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019. The Lancet Healthy Longevity. 2021;2(9):e580-e592.
BibTex	@article{ author = {Wu AM and Bisignano C and James SL and Abady GG and Abedi A and Abugharbieh E and Alhassan RK and Alipour V and Arabloo J and Asaad M and Asmare WN and Awedew AF and Banach M and Banerjee SK and Bijani A and Birhanu TTM and Bolla SR and Camera LA and Chang JC and Cho DY and Chung MY and Couto RAS and Dai X and Dandona L and Dandona R and Farzadfar F and Filip I and Fischer F and Fomenkov AA and Gill TK and Gupta B and Haagsma JA and Hajmirzaian A and Hamidi S and Hay SI and Ilic IM and Ilic MD and Ivers RQ and Jurisson M and Kalhor R and Kanchan T and Kavetskyy T and Khalilov R and Khan EA and Khan M and Kneib CJ and Krishnamoorthy V and Kumar GA and Kumar N and Lalloo R and Lasrado S and Lim SS and Liu Z and Manafi A and Manafi N and Menezes RG and Meretoja TJ and Miazgowski B and Miller TR and Mohammad Y and Mohammadianhafshejani A and Mokdad AH and Murray CJL and Naderi M and Naimzada MD and Nayak VC and Nguyen CT and Nikbakhsh R and Olagunju AT and Otstavnov N and Otstavnov SS and Padubidri JR and Pereira J and Pham HQ and Pinheiro M and Polinder S and Pourchamani H and Rabiee N and Radfar A and Ur Rahman MH and Rawaf DL and Rawaf S and Saeb MR and Samy AM and Riera LS and Schwebel DC and Shahabi S and Shaikh MA and Soheili A and Tabaresseisdedos R and Tovanipalone MR and Tran BX and Travillian RS and Valdez PR and Vasankari TJ and Velazquez DZ and Venketasubramanian N and Vu GT and Zhang ZJ and Vos T}, title = {Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019}, journal = {The Lancet Healthy Longevity}, volume = {2}, number = {9}, pages = {e580-e592}, year = {2021} }
RIS	TY - JOUR AU - Wu AM AU - Bisignano C AU - James SL AU - Abady GG AU - Abedi A AU - Abugharbieh E AU - Alhassan RK AU - Alipour V AU - Arabloo J AU - Asaad M AU - Asmare WN AU - Awedew AF AU - Banach M AU - Banerjee SK AU - Bijani A AU - Birhanu TTM AU - Bolla SR AU - Camera LA AU - Chang JC AU - Cho DY AU - Chung MY AU - Couto RAS AU - Dai X AU - Dandona L AU - Dandona R AU - Farzadfar F AU - Filip I AU - Fischer F AU - Fomenkov AA AU - Gill TK AU - Gupta B AU - Haagsma JA AU - Hajmirzaian A AU - Hamidi S AU - Hay SI AU - Ilic IM AU - Ilic MD AU - Ivers RQ AU - Jurisson M AU - Kalhor R AU - Kanchan T AU - Kavetskyy T AU - Khalilov R AU - Khan EA AU - Khan M AU - Kneib CJ AU - Krishnamoorthy V AU - Kumar GA AU - Kumar N AU - Lalloo R AU - Lasrado S AU - Lim SS AU - Liu Z AU - Manafi A AU - Manafi N AU - Menezes RG AU - Meretoja TJ AU - Miazgowski B AU - Miller TR AU - Mohammad Y AU - Mohammadianhafshejani A AU - Mokdad AH AU - Murray CJL AU - Naderi M AU - Naimzada MD AU - Nayak VC AU - Nguyen CT AU - Nikbakhsh R AU - Olagunju AT AU - Otstavnov N AU - Otstavnov SS AU - Padubidri JR AU - Pereira J AU - Pham HQ AU - Pinheiro M AU - Polinder S AU - Pourchamani H AU - Rabiee N AU - Radfar A AU - Ur Rahman MH AU - Rawaf DL AU - Rawaf S AU - Saeb MR AU - Samy AM AU - Riera LS AU - Schwebel DC AU - Shahabi S AU - Shaikh MA AU - Soheili A AU - Tabaresseisdedos R AU - Tovanipalone MR AU - Tran BX AU - Travillian RS AU - Valdez PR AU - Vasankari TJ AU - Velazquez DZ AU - Venketasubramanian N AU - Vu GT AU - Zhang ZJ AU - Vos T TI - Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019 JO - The Lancet Healthy Longevity VL - 2 IS - 9 SP - e580 EP - e592 PY - 2021 ER -

Style

Citing Format

MLA

Wu AM, et al.. "Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019." The Lancet Healthy Longevity, vol. 2, no. 9, 2021, pp. e580-e592.

APA

Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abugharbieh E, Alhassan RK, Alipour V, Arabloo J, Asaad M, Asmare WN, Awedew AF, Banach M, Banerjee SK, Bijani A, Birhanu TTM, Bolla SR, Camera LA, Chang JC, ... Vos T (2021). Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019. The Lancet Healthy Longevity, 2(9), e580-e592.

Chicago

Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abugharbieh E, Alhassan RK, et al.. "Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019." The Lancet Healthy Longevity 2, no. 9 (2021): e580-e592.

Harvard

Wu AM et al. (2021) 'Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019', The Lancet Healthy Longevity, 2(9), pp. e580-e592.

Vancouver

Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abugharbieh E, et al.. Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019. The Lancet Healthy Longevity. 2021;2(9):e580-e592.

BibTex

@article{ author = {Wu AM and Bisignano C and James SL and Abady GG and Abedi A and Abugharbieh E and Alhassan RK and Alipour V and Arabloo J and Asaad M and Asmare WN and Awedew AF and Banach M and Banerjee SK and Bijani A and Birhanu TTM and Bolla SR and Camera LA and Chang JC and Cho DY and Chung MY and Couto RAS and Dai X and Dandona L and Dandona R and Farzadfar F and Filip I and Fischer F and Fomenkov AA and Gill TK and Gupta B and Haagsma JA and Hajmirzaian A and Hamidi S and Hay SI and Ilic IM and Ilic MD and Ivers RQ and Jurisson M and Kalhor R and Kanchan T and Kavetskyy T and Khalilov R and Khan EA and Khan M and Kneib CJ and Krishnamoorthy V and Kumar GA and Kumar N and Lalloo R and Lasrado S and Lim SS and Liu Z and Manafi A and Manafi N and Menezes RG and Meretoja TJ and Miazgowski B and Miller TR and Mohammad Y and Mohammadianhafshejani A and Mokdad AH and Murray CJL and Naderi M and Naimzada MD and Nayak VC and Nguyen CT and Nikbakhsh R and Olagunju AT and Otstavnov N and Otstavnov SS and Padubidri JR and Pereira J and Pham HQ and Pinheiro M and Polinder S and Pourchamani H and Rabiee N and Radfar A and Ur Rahman MH and Rawaf DL and Rawaf S and Saeb MR and Samy AM and Riera LS and Schwebel DC and Shahabi S and Shaikh MA and Soheili A and Tabaresseisdedos R and Tovanipalone MR and Tran BX and Travillian RS and Valdez PR and Vasankari TJ and Velazquez DZ and Venketasubramanian N and Vu GT and Zhang ZJ and Vos T}, title = {Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019}, journal = {The Lancet Healthy Longevity}, volume = {2}, number = {9}, pages = {e580-e592}, year = {2021} }

RIS

TY - JOUR
AU - Wu AM
AU - Bisignano C
AU - James SL
AU - Abady GG
AU - Abedi A
AU - Abugharbieh E
AU - Alhassan RK
AU - Alipour V
AU - Arabloo J
AU - Asaad M
AU - Asmare WN
AU - Awedew AF
AU - Banach M
AU - Banerjee SK
AU - Bijani A
AU - Birhanu TTM
AU - Bolla SR
AU - Camera LA
AU - Chang JC
AU - Cho DY
AU - Chung MY
AU - Couto RAS
AU - Dai X
AU - Dandona L
AU - Dandona R
AU - Farzadfar F
AU - Filip I
AU - Fischer F
AU - Fomenkov AA
AU - Gill TK
AU - Gupta B
AU - Haagsma JA
AU - Hajmirzaian A
AU - Hamidi S
AU - Hay SI
AU - Ilic IM
AU - Ilic MD
AU - Ivers RQ
AU - Jurisson M
AU - Kalhor R
AU - Kanchan T
AU - Kavetskyy T
AU - Khalilov R
AU - Khan EA
AU - Khan M
AU - Kneib CJ
AU - Krishnamoorthy V
AU - Kumar GA
AU - Kumar N
AU - Lalloo R
AU - Lasrado S
AU - Lim SS
AU - Liu Z
AU - Manafi A
AU - Manafi N
AU - Menezes RG
AU - Meretoja TJ
AU - Miazgowski B
AU - Miller TR
AU - Mohammad Y
AU - Mohammadianhafshejani A
AU - Mokdad AH
AU - Murray CJL
AU - Naderi M
AU - Naimzada MD
AU - Nayak VC
AU - Nguyen CT
AU - Nikbakhsh R
AU - Olagunju AT
AU - Otstavnov N
AU - Otstavnov SS
AU - Padubidri JR
AU - Pereira J
AU - Pham HQ
AU - Pinheiro M
AU - Polinder S
AU - Pourchamani H
AU - Rabiee N
AU - Radfar A
AU - Ur Rahman MH
AU - Rawaf DL
AU - Rawaf S
AU - Saeb MR
AU - Samy AM
AU - Riera LS
AU - Schwebel DC
AU - Shahabi S
AU - Shaikh MA
AU - Soheili A
AU - Tabaresseisdedos R
AU - Tovanipalone MR
AU - Tran BX
AU - Travillian RS
AU - Valdez PR
AU - Vasankari TJ
AU - Velazquez DZ
AU - Venketasubramanian N
AU - Vu GT
AU - Zhang ZJ
AU - Vos T
TI - Global, Regional, and National Burden of Bone Fractures in 204 Countries and Territories, 1990–2019: A Systematic Analysis From the Global Burden of Disease Study 2019
JO - The Lancet Healthy Longevity
VL - 2
IS - 9
SP - e580
EP - e592
PY - 2021
ER -

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