Bladder Dysfunction Publisher



Aghamir SMK¹ ; Guitynavard F¹
Source: Stem Cells in Urology Published:2020

Abstract

The studies focusing on the use of stem cells in treatment of different medical condition is growing over the time. But yet a few studies conducted to evaluate efficacy and safety of stem cell therapy in different types of bladder dysfunction. In addition, these studies are mainly focuse on experimental models rather than tissue engineering and bladder regeneration. There are some defined models of bladder dysfunction in literature: bladder outlet obstruction, cryoinjured, diabetes, ischemia, and spinal cord injury models. Among the different subgroups of stem cells, adipose derived stem cells (ADSCs), skeletal muscle derived stem cells (SkMSCs) and bone marrow stem cells (BMSCs) are used more commonly in favor of bladder dysfunction treatment. These stem cells with unique characteristics and multiple mechanisms of action (migration, differentiation and their paracrine effect) are so suitable for using in different clinical approaches to treat bladder dysfunction including bladder bioengineering and bioprinting. This chapter is aimed at providing the current status of using stem cells for bladder dysfunction treatment as well as exploring future prospects on this topic. © Springer Nature Switzerland AG 2020.