Il-33/St2 Axis in Autoimmune Disease Publisher Pubmed



Shakerian L¹ ; Kolahdooz H² ; Garousi M³ ; Keyvani V⁴ ; Kamal Kheder R^{5, 6} ; Abdulsattar Faraj T^{6, 7} ; Yazdanpanah E^{2, 8} ; Esmaeili SA^{2, 8}
Source: Cytokine Published:2022

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, NK cells, and T lymphocyte cells. The vital role of IL-33 as an active component gives rise to aberrant local and systemic damage which has been demonstrated in numerous inflammatory disorders and immune-mediated pathological conditions including multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, Sjogren's syndrome, inflammatory bowel disease (IBD), etc. IL-33/ST2 axis can up-regulate pro-inflammatory cytokine release in autoimmune disease, however, in some metabolic diseases like diabetes mellitus type 1 IL-33 can be considered an anti-inflammatory cytokine. The purpose of this review is to discuss selected studies on IL-33/ST2 axis in autoimmune diseases and its potential role as a pathogenic or protective cytokine. © 2022