Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases

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Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases Publisher Pubmed

Sanati G¹ ; Aryan Z^{1, 3} ; Barbadi M² ; Rezaei N^{2, 4, 5}

Source: Expert Review of Clinical Immunology Published:2015

Abstract

Innate lymphoid cells (ILCs) are lymphoid cells that do not express V(D)J-rearranged receptors and play a role in the innate immune system. ILCs are categorized into three groups with respect to their function in the immune system. ILC1 induces production of IFN-γ via T-box expressed on T cells, ILC2 promotes production of type 2 cytokines via GATA-binding protein-3 and ILC3 promotes IL-17 and IL-22 production via retinoic acid receptor-related orphan receptor-γt. ILCs can maintain homeostasis in epithelial surfaces by responding to locally produced cytokines or direct recognition of danger patterns. Altered epithelial barrier function seems to be a key point in inappropriate activation of ILCs to promote inflammatory and allergic responses. ILCs play an essential role in initiation and maintenance of defense against infections as well as immune-mediated diseases. In this paper, we discuss the role of ILCs in inflammatory, allergic and autoimmune diseases. © 2015 Informa UK, Ltd.

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Style	Citing Format
MLA	Sanati G, et al.. "Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases." Expert Review of Clinical Immunology, vol. 11, no. 8, 2015, pp. 885-895.
APA	Sanati G, Aryan Z, Barbadi M, Rezaei N (2015). Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases. Expert Review of Clinical Immunology, 11(8), 885-895.
Chicago	Sanati G, Aryan Z, Barbadi M, Rezaei N. "Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases." Expert Review of Clinical Immunology 11, no. 8 (2015): 885-895.
Harvard	Sanati G et al. (2015) 'Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases', Expert Review of Clinical Immunology, 11(8), pp. 885-895.
Vancouver	Sanati G, Aryan Z, Barbadi M, Rezaei N. Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases. Expert Review of Clinical Immunology. 2015;11(8):885-895.
BibTex	@article{ author = {Sanati G and Aryan Z and Barbadi M and Rezaei N}, title = {Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases}, journal = {Expert Review of Clinical Immunology}, volume = {11}, number = {8}, pages = {885-895}, year = {2015} }
RIS	TY - JOUR AU - Sanati G AU - Aryan Z AU - Barbadi M AU - Rezaei N TI - Innate Lymphoid Cells Are Pivotal Actors in Allergic, Inflammatory and Autoimmune Diseases JO - Expert Review of Clinical Immunology VL - 11 IS - 8 SP - 885 EP - 895 PY - 2015 ER -

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