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N-(2-(Piperazin-1-Yl)Phenyl)Arylamide Derivatives As Β-Secretase (Bace1) Inhibitors: Simple Synthesis by Ugi Four-Component Reaction and Biological Evaluation Publisher Pubmed



Edraki N1 ; Firuzi O1 ; Fatahi Y2 ; Mahdavi M2 ; Asadi M2 ; Emami S3 ; Divsalar K4 ; Miri R1 ; Iraji A1 ; Khoshneviszadeh M1 ; Firoozpour L5 ; Shafiee A2 ; Foroumadi A2
Authors

Source: Archiv der Pharmazie Published:2015


Abstract

A novel series of N-(2-(piperazin-1-yl)phenyl)aryl carboxamide derivatives were simply synthesized by Ugi-multicomponent reaction as β-secretase (BACE1) inhibitors. The BACE1 inhibitory activity of the synthesized compounds was examined using a Forester resonance energy transfer (FRET)-based assay. Among the tested compounds, the N-(5-bromo-2-(4-phenylpiperazine-1-yl)phenyl)thiophene-carboxamide derivative 14 containing the N-cyclohexyl indole acetamide moiety showed superior BACE1 inhibition at 10 and 40 μM. The results of the molecular docking study indicated that compound 14 establishes favorable hydrogen bonding interactions with the catalytic amino acid residues Asp228 and Thr72 and could be well accommodated in the flap region and P2 and P′2 pockets of the BACE1 active site. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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