Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Adapted Dexamethasone Delivery Polyethylene Oxide and Poly(E-Caprolactone) Construct Promote Mesenchymal Stem Cells Chondrogenesis Publisher Pubmed



Ghiaee A1 ; Pournaqi F1 ; Vakilian S2 ; Mohammadisangcheshmeh A3 ; Ardeshirylajimi A4
Authors

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017


Abstract

Issues associated with tissue transplantation and shortage of donors has always been a concern, whereas tissue engineering has provided the hopeful opportunities. The aim of this study was to investigate the chondrogenic differentiation potential of mesenchymal stem cells (MSCs) in the presence of embedded Dexamethasone into electrospun Poly(ethyleneoxide) nanofibers composited with Poly(e-caprolactone) nanofibers. Electrospun-fabricated scaffolds were characterized by SEM, tensile, contact angle, release profile, MTT assay, and chonderogenic differentiation of stem cells. Results demonstrated Poly(e-caprolactone) properties improved by composite with a Poly(ethyleneoxide). Overall, stem cells seeded on nanofibers content drug showed highest chondrogenic potential in comparison to the other groups. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Enhanced Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells on Pcl/Plga Electrospun With Different Alignments and Compositions, International Journal of Polymeric Materials and Polymeric Biomaterials (2018)
2. The Effect of Nanofibre-Based Polyethersulfone (Pes) Scaffold on the Chondrogenesis of Human Induced Pluripotent Stem Cells, Artificial Cells# Nanomedicine and Biotechnology (2018)
3. Bone Tissue Engineering: Adult Stem Cells in Combination With Electrospun Nanofibrous Scaffolds, Journal of Cellular Physiology (2018)
Experts (# of related papers)
View all Related Experts
Mohammad Vasei (1)
Mohsen Amini (1)
Other Related Docs
4. Renal Differentiation of Mesenchymal Stem Cells Seeded on Nanofibrous Scaffolds Improved by Human Renal Tubular Cell Lines-Conditioned Medium, ASAIO Journal (2017)
5. In Vitro Osteogenic Differentiation of Stem Cells With Different Sources on Composite Scaffold Containing Natural Bioceramic and Polycaprolactone, Artificial Cells# Nanomedicine and Biotechnology (2019)
6. Influence of Oriented Nanofibrous Pcl Scaffolds on Quantitative Gene Expression During Neural Differentiation of Mouse Embryonic Stem Cells, Journal of Biomedical Materials Research - Part A (2016)
7. Designing Nanofiber Multilayer Composite Scaffolds and Lyophilized Blood Growth Factors in the Process of Osteogenesis, Journal of Mazandaran University of Medical Sciences (2022)
8. Evaluation of Viability and Cell Attachment of Human Endometrial Stem Cells on Electrospun Silk Scaffolds Prepared Under Different Degumming Conditions and Solvents, Regenerative Engineering and Translational Medicine (2022)
9. Promoting Osteogenic Differentiation of Human-Induced Pluripotent Stem Cells by Releasing Wnt/Β-Catenin Signaling Activator From the Nanofibers, Journal of Cellular Biochemistry (2019)
10. Hybrid Electrospun Scaffold Loaded With Argireline Acetate and Dexpanthenol for Skin Regeneration, International Journal of Polymeric Materials and Polymeric Biomaterials (2023)
11. Platelet-Rich Plasma Incorporated Electrospun Pva-Chitosan-Ha Nanofibers Accelerates Osteogenic Differentiation and Bone Reconstruction, Gene (2019)
12. Baghdadite Nanoparticle-Coated Poly L-Lactic Acid (Plla) Ceramics Scaffold Improved Osteogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells, Journal of Biomedical Materials Research - Part A (2019)
13. Nanofibrous Scaffolds Containing Hydroxyapatite and Microfluidic-Prepared Polyamidoamin/Bmp-2 Plasmid Dendriplexes for Bone Tissue Engineering Applications, International Journal of Nanomedicine (2020)
14. Improved Chondrogenic Response of Mesenchymal Stem Cells to a Polyethersulfone/Polyaniline Blended Nanofibrous Scaffold, Journal of Cellular Biochemistry (2019)
15. Synthesis and Characterization of Electrospun Cerium-Doped Bioactive Glass/Chitosan/Polyethylene Oxide Composite Scaffolds for Tissue Engineering Applications, Ceramics International (2021)
16. Electrical Stimulation of Somatic Human Stem Cells Mediated by Composite Containing Conductive Nanofibers for Ligament Regeneration, Biologicals (2017)
17. Layered Dermal Reconstitution Through Epigallocatechin 3-Gallate Loaded Chitosan Nanoparticle Within Enzymatically Crosslinked Polyvinyl Alcohol/Collagen Fibrous Mat, Journal of Biomaterials Applications (2022)
18. Adipose-Derived Stem Cells-Conditioned Medium Improved Osteogenic Differentiation of Induced Pluripotent Stem Cells When Grown on Polycaprolactone Nanofibers, Journal of Cellular Physiology (2019)
19. Biological Behavior of the Curcumin Incorporated Chitosan/Poly(Vinyl Alcohol) Nanofibers for Biomedical Applications, Journal of Cellular Biochemistry (2019)
20. Comparison of Human-Induced Pluripotent Stem Cells and Mesenchymal Stem Cell Differentiation Potential to Insulin Producing Cells in 2D and 3D Culture Systems in Vitro, Journal of Cellular Physiology (2020)