Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Cubr-Catalysed One-Pot Multicomponent Synthesis of 3-Substituted 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Publisher



Sayahi MH1 ; Saghanezhad SJ2 ; Bahadorikhalili S3 ; Mahdavi M4
Authors

Source: Applied Organometallic Chemistry Published:2019


Abstract

A novel methodology is presented for the synthesis of 3-substituted 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives based on an efficient tandem multicomponent reaction using copper bromide as catalyst. This methodology is based on the multicomponent one-pot reaction of methyl 2-bromobenzoate, phenylisothiocyanate derivatives and sodium azide in the presence of copper bromide and l-proline under basic conditions. To show the generality of the method, various phenylisothiocyanates bearing electron-donating or electron-withdrawing functionalities were used and the desired products were obtained in high isolated yields. © 2018 John Wiley & Sons, Ltd.
Related Docs
View other Related Docs
1. Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions, ChemistrySelect (2019)
2. Green Synthesis of 2-((2-Aryl-3-Oxoisoindolin-1-Yl)Methyl)Quinazolin-4(3H)-Ones Via Sequential Condensation, Sp3 C–H Bond Functionalization and Cyclization, Tetrahedron Letters (2018)
3. A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives, Iranian Journal of Chemistry and Chemical Engineering (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (19)
Alireza Foroumadi (6)
Other Related Docs
4. A Green and Efficient Synthesis of 2-Thioxoquinazolinone Derivatives in Water Using Potassium Thiocyanate, Journal of Sulfur Chemistry (2017)
5. Efficient Synthesis of 3-Alkyl-2-(-1H-1,2,3-Triazolyl)Methyl)Thio)-2,3-Dihydroquinazolin-4(1H)-One Derivative Via Multistep Synthesis Approach by Novel Cu@Py-Oxa@Spion Catalyst, BMC Chemistry (2023)
6. Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One, Monatshefte fur Chemie (2016)
7. A Facile, One-Pot, and Green Method for Synthesis of 2-Aryl-3-(Phenylamino)Dihydroquinazolin-4(1H)-One Derivatives Using Sodium Lauryl Sulfate (Sls) in Aqueous Media at the Room Temperature, Polycyclic Aromatic Compounds (2024)
8. Dabco-Catalyzed Easy Access to Benzo[D]Naphtho[2,3-G][1,3]-Oxazocine-8,13(6H,14H)-Diones in Aqueous Media, Iranian Journal of Chemistry and Chemical Engineering (2021)
9. Copper-Catalyzed Synthesis of 2,3-Disubstituted Quinazolin-4(3H)-Ones From Benzyl-Substituted Anthranilamides, Heterocyclic Communications (2018)
10. Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones, New Journal of Chemistry (2018)
11. Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives, Journal of the Chinese Chemical Society (2021)
12. Copper Catalyst-Supported Modified Magnetic Chitosan for the Synthesis of Novel 2-Arylthio-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via Chan–Lam Coupling, Inorganics (2022)
13. Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles, Organic and Biomolecular Chemistry (2025)
14. Tandem Synthesis of Benzo[D]Naphtho[2,3-G][1,3]Oxazocine-8,13(6H,14H)-Dione Derivatives, Monatshefte fur Chemie (2019)
15. Synthesis of Quinazolin-4(3H)-Ones Via the Reaction of Isatoic Anhydride With Benzyl Azides in the Presence of Potassium Tert-Butoxide in Dmso, Chemistry of Heterocyclic Compounds (2019)
16. Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion, Applied Organometallic Chemistry (2020)
17. Copper-Catalyzed One-Pot Synthesis of Amide Linked 1,2,3-Triazoles Bearing Aryloxy Skeletons, Tetrahedron Letters (2021)
18. A Novel Copper-Catalyzed Preparation of Pyrido[1,2- a ]Pyrimidine Derivatives, Synlett (2016)
19. Utilizing Amines and Carbon Disulfide to Obtain Nitrogen-And Sulfur-Containing Compounds Under Green Conditions: A Review, Current Organic Chemistry (2018)
20. Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones, Helvetica Chimica Acta (2016)