Optimal Cutoff Points for Homa-Ir and Quicki in the Diagnosis of Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Population Based Study Publisher Pubmed



Motamed N¹ ; Miresmail SJH² ; Rabiee B³ ; Keyvani H⁴ ; Farahani B³ ; Maadi M³ ; Zamani F³
Source: Journal of Diabetes and its Complications Published:2016

Abstract

Aims The present study was carried out to determine the optimal cutoff points for homeostatic model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) in the diagnosis of metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). Methods The baseline data of 5511 subjects aged ≥ 18 years of a cohort study in northern Iran were utilized to analyze. Receiver operating characteristic (ROC) analysis was conducted to determine the discriminatory capability of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. Youden index was utilized to determine the optimal cutoff points of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. Results The optimal cutoff points for HOMA-IR in the diagnosis of MetS and NAFLD were 2.0 [sensitivity = 64.4%, specificity = 66.8%] and 1.79 [sensitivity = 66.2%, specificity = 62.2%] in men and were 2.5 [sensitivity = 57.6%, specificity = 67.9%] and 1.95 [sensitivity = 65.1%, specificity = 54.7%] in women respectively. Furthermore, the optimal cutoff points for QUICKI in the diagnosis of MetS and NAFLD were 0.343 [sensitivity = 63.7%, specificity = 67.8%] and 0.347 [sensitivity = 62.9%, specificity = 65.0%] in men and were 0.331 [sensitivity = 55.7%, specificity = 70.7%] and 0.333 [sensitivity = 53.2%, specificity = 67.7%] in women respectively. Conclusion Not only the optimal cutoff points of HOMA-IR and QUICKI were different for MetS and NAFLD, but also different cutoff points were obtained for men and women for each of these two conditions. © 2016 Elsevier Inc. All rights reserved.