Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Association of Dietary Phytochemical Index and Anthropometric Risk Factors With Non-Alcoholic Fatty Liver Disease in People With Diabetes



Soltanieh S1 ; Salavatizadeh M1 ; Poustchi H2 ; Yari Z3 ; Mansour A4 ; Khamseh ME5 ; Malek M6 ; Alaeishahmiri F5 ; Hekmatdoost A1
Authors

Source: Iranian Journal of Nutrition Sciences and Food Technology Published:2023

Abstract

Background and Objectives: High prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus results in deleterious complications and morbidities. Therefore, the aim of this study was to assess nutritional and anthropometrical risk factors in progression of non-alcoholic fatty liver disease in diabetic patients. Materials & Methods: Totally, 133 non-alcoholic fatty liver disease patients (CAP score > 270) and 67 controls (CAP score < 270) were selected from the patients with type 2 diabetes mellitus in a clinic. Dietary phytochemical index was calculated via data from a validated 147-item FFQ. Body composition were measured using dual-energy X-ray absorptiometry. Other anthropometric indices and laboratory assays were used as well. Logistic regression models were used to estimate multivariable ORs. Results: After adjustment for potential confounders, risk of progression for non-alcoholic fatty liver disease in participants with higher dietary phytochemical indices significantly decreased (OR = 0.35, 95% CI: 0.12–0.98, p = 0.048). After fully adjustment of covariates and independently from body mass index, positive associations were seen between the highest tertile of TLR (OR = 7.99, 95% CI: 2.43–26.26, p = 0.001), METS-VF (OR = 4.55, 95% CI: 1.46–14.2, p = 0.009) and risk of non-alcoholic fatty liver disease. Conclusion: Findings of this study have demonstrated that phytochemical components of diet play protective roles against non-alcoholic fatty liver disease. Moreover, TLR and METS-VF are addressed as novel estimators of central obesity as a risk factor for non-alcoholic fatty liver disease in diabetes. © 2023, National Nutrition and Food Technology Research Institute. All rights reserved.
Related Docs
View other Related Docs
1. The Association of Dietary Inflammatory Index (Dii) and Central Obesity With Non-Alcoholic Fatty Liver Disease (Nafld) in People With Diabetes (T2dm), Heliyon (2023)
2. Association of Dietary Phytochemical Index With Cardiometabolic Risk Factors a Systematic Review and Meta-Analysis on Observational Studies, International Journal for Vitamin and Nutrition Research (2023)
3. Dietary Phytochemical Index Is Favorably Associated With Oxidative Stress Status and Cardiovascular Risk Factors in Adults With Obesity, Scientific Reports (2023)
Experts (# of related papers)
View all Related Experts
Hossein Poustchi (5)
Khadijeh Mirzaei (3)
Other Related Docs
4. High Intake of Dietary Phytochemical Index May Be Related to Reducing Risk of Diabetic Nephropathy: A Case–Control Study, BMC Nutrition (2023)
5. The Relationship Between Dietary Phytochemical Index and Novel Anthropometric Indices and the Severity of Diabetic Foot Ulcers in Adults With Type 2 Diabetes: A Cross-Sectional Study, BMC Endocrine Disorders (2024)
6. Dietary Phytochemical Index Associated With Cardiovascular Risk Factor in Patients With Type 1 Diabetes Mellitus, BMC Cardiovascular Disorders (2021)
7. The Relationship Between Dietary Phytochemical Index and Resting Metabolic Rate Mediated by Inflammatory Factors in Overweight and Obese Women: A Cross-Sectional Study, BMC Women's Health (2022)
8. Association of the Dietary Phytochemical Index With General and Central Obesity in a Sample of Iranian Adults, Journal of Functional Foods (2021)
9. Higher Dietary Phytochemical Index Is Associated With Anthropometric Indices in Children and Adolescents: The Weight Disorders Survey of the Caspian-Iv Study, International Journal for Vitamin and Nutrition Research (2021)
10. Association of Dietary Phytochemical Index With Metabolically Unhealthy Overweight/Obesity Phenotype Among Iranian Women: A Cross-Sectional Study, Frontiers in Nutrition (2022)
11. The Efficacy of Dash Combined With Time-Restricted Feeding (16/8) on Metabolic Associated Fatty Liver Disease Management: A Randomized Controlled Trial, Scientific Reports (2025)
12. Interaction Between Cetp Taq1b Polymorphism and Hei, Dqi and Dpi on Metabolic Biomarkers in Patients With Type 2 Diabetes, Journal of Human Nutrition and Dietetics (2022)
13. Associations Between Ultra-Processed Foods and Risk of Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Cross-Sectional Study, Iranian Journal of Nutrition Sciences and Food Technology (2025)
14. The Relation Between Dietary Phytochemical Index and Metabolic Health Status in Overweight and Obese Adolescents, Scientific Reports (2023)
15. The Association of the Healthy Food Diversity Index With the Risk of Non-Alcoholic Fatty Liver Disease Among the Adult Population, Clinical Nutrition ESPEN (2024)
16. Recent Advances in Dietary Supplementation, in Treating Non-Alcoholic Fatty Liver Disease, World Journal of Hepatology (2015)
17. The Association Between Dietary Acid Load and Odds of Non-Alcoholic Fatty Liver Disease: A Case-Control Study, Nutrition and Health (2023)
18. The Potential Causal Effect of the Pre-Pregnancy Dietary Phytochemical Index on Gestational Diabetes Mellitus: A Prospective Cohort Study, BMC Pregnancy and Childbirth (2024)
19. Association of Dietary Phytochemical Index With Metabolic Markers, Serum Asymmetric Dimethylarginine and Atherogenic Indices in Patients With Polycystic Ovary Syndrome, Nutrition and Metabolism (2025)
20. Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Biochemical and Anthropometric Factors in Type 2 Diabetes Mellitus, Scientific Reports (2021)