Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Experimental and Computational Evidence for Kot-Bu-Promoted Synthesis of Oxopyrazino[1,2-A]Indoles Publisher



Mahdavi M1 ; Hassanzadehsoureshjan R2 ; Saeedi M3, 4 ; Ariafard A5, 6 ; Babaahmadi R6 ; Ranjbar PR2 ; Shafiee A1
Authors

Source: RSC Advances Published:2015


Abstract

A novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction. © The Royal Society of Chemistry.