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Mir-148 and Mir-375 Expression in Oral Squamous Cell Carcinoma Patients With Oral Infection in Comparison With Oscc Patients Without Oral Infection Publisher



Bahrami N ; Hosseini F ; Hajmali M ; Mohamadnia A ; Tehrani MM ; Farhangiyan M
Authors

Source: Journal of Craniomaxillofacial Research Published:2024


Abstract

Introduction: Oral squamous cell carcinoma is a multifactorial disease that is the sixth most common cancer worldwide. MicroRNAs have been confirmed to play a role in oral squamous cell carcinoma, acting as either oncogenes or tumor suppressor genes. This study examined the expression level and role of microR-148 and microR-375 in oral cancer. Materials and Methods: In this study, we used 30 cancer samples with infection and 30 cancer samples without infection. To analyze the expression of microRNA 375 and microRNA 148, we used real-time PCR. First, we extracted total RNA from the samples. Then, we generated cDNA from it. Finally, the obtained cDNA was used in the real-time PCR technique. Results: In cancer patients with oral infection, there was an increase in microRNA-148 expression and a decrease in microRNA-375 compared to cancer patients without oral infection. Conclusion: The downregulation of microRNA-375 and upregulation of microRNA-148 can be utilized as diagnostic biomarkers and prognostic factors in oral cancer. © 2024 Tehran University of Medical Sciences.
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