The Expression of Microrna-155 (Mir-155) and Carcinoembryonic Antigen Messenger Rna (Cea Mrna) in Peripheral Blood of Patients With Oral Squamous Cell Carcinomas (Oscc) Publisher



Narimani A¹ ; Hosseini F² ; Bahrami N³ ; Mohamadnia A⁴
Source: Journal of Isfahan Medical School Published:2019

Abstract

Background: Oral squamous cell carcinoma (OSCC) accounts for about 90% of all malignant oral tumors, and is often diagnosed in advanced stages. In this study, changes in the expression of microRNA-155 (miR-155) and carcinoembryonic antigen messenger RNA (CEA mRNA) in peripheral blood of patients with oral cancer were investigated. Methods: In this study, 30 patients and 30 healthy people were selected. The miR-155 and CEA mRNA levels in their peripheral blood were measured and evaluated using real-time polymerase chain reaction (real-time PCR) technique. Findings: Positive miR-155 marker was observed in 21 people from 30 with oral cancer, and 7 of 30 healthy subjects. The CEA mRNA marker was positive in 23 of the 30 patients, and 5 out of 30 healthy subjects. Conclusion: In sum, the outcome of this study can be seen as a screening diagnostic test for early detection of the disease in the early stages. © 2019, Isfahan University of Medical Sciences(IUMS). All rights reserved.