Chitosan-Encapsulated Lipid-Based Nanovesicles for Therapeutic Applications and Tissue Engineering: A Review Publisher



Vosoughi P¹ ; Naghib SM¹ ; Jafari T¹ ; Kangarshahi BM^{1, 2}
Source: Carbohydrate Polymer Technologies and Applications Published:2025

Abstract

This review provides a comprehensive examination of polysaccharides, with a particular focus on lipid-based nanovesicles that have been modified with chitosan. It delves into chitosan's unique properties to these nanovesicles, enhancing their stability, biocompatibility, and drug delivery capabilities. The review delves into the diverse application routes for modified nanovesicles, highlighting their effectiveness across clinical and therapeutic contexts. Specific areas of focus include targeted drug delivery, where the precision of these nanovesicles can enhance the localization of therapeutic agents directly to cancer cells, thereby reducing side effects and enhanced effectiveness. It also examines their role in other therapies, showcasing how these carriers can facilitate the safe delivery of materials and therapeutics to cells. Furthermore, the review addresses how chitosan-coated lipid nanovesicles can improve vaccine components, stability, bioavailability, and immunogenicity, enhancing the overall immune responses. By considering the insights from recent studies and findings, this comprehensive analysis emphasizes the remarkable versatility and promising potential of chitosan-coated lipid nanovesicles, positioning them as a significant asset in the progression of biomedical applications. © 2025 The Author(s)