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An Efficient Four-Step Approach Toward Fused Triazino[1,6-A] Quinazolines Publisher Pubmed



Sayahi MH1 ; Baghersaei S1 ; Goli F2 ; Moghimi S2 ; Mahdavi M2 ; Firoozpour L3 ; Shafiee A2 ; Foroumadi A2, 3
Authors

Source: Combinatorial Chemistry and High Throughput Screening Published:2016


Abstract

Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6-a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields. © 2016 Bentham Science Publishers.
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