Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective Publisher



Etemadi A1 ; Moradi HR1 ; Mohammadian F2 ; Karimijafari MH3 ; Negahdari B1 ; Asgari Y1 ; Mazloomi M1
Authors

Source: Gene Reports Published:2022


Abstract

Introduction: The COVID-19 pandemic is now affecting all people around the world and getting worse. New antiviral medications are desperately needed other than the few approved medications that have shown no promising efficacy so far. Methods: Here we report three blocking binders for targeting SARS-CoV-2 spike protein to block the interaction between the spike protein on the SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) receptors, responsible for viral homing into the alveolar epithelium type II cells (AECII). Results: The design process is based on the collected natural scaffolds and using Rosetta interface for designing the binders. Conclusion: Based on the structural analysis, three binders were selected, and the results showed that they might be promising as new therapeutic targets for blocking COVID-19. © 2021
Other Related Docs
6. Design of a Multi-Epitope Vaccine Against Sars-Cov-2 Using Immunoinformatics Approach, International Journal of Biological Macromolecules (2020)
12. Potential Therapeutic Options for Covid-19: An Update on Current Evidence, European Journal of Medical Research (2022)
16. Molecular Aspects of Co-Morbidities in Covid-19 Infection, Archives of Bone and Joint Surgery (2020)