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Evaluation of Patients With Primary Immunodeficiency Associated With Bacille Calmette-Guerin (Bcg)-Vaccine-Derived Complications Publisher Pubmed



Sohani M1 ; Habibi S1 ; Delavari S1 ; Shahkarami S1, 2 ; Yazdani R1, 3 ; Shirmast P1 ; Nazari F1 ; Moeini Shad T1 ; Mamishi S4 ; Azizi G5 ; Anka AU6 ; Hassanpour G7 ; Kalantari A8 ; Shariat M9 Show All Authors
Authors
  1. Sohani M1
  2. Habibi S1
  3. Delavari S1
  4. Shahkarami S1, 2
  5. Yazdani R1, 3
  6. Shirmast P1
  7. Nazari F1
  8. Moeini Shad T1
  9. Mamishi S4
  10. Azizi G5
  11. Anka AU6
  12. Hassanpour G7
  13. Kalantari A8
  14. Shariat M9
  15. Shafiei A10
  16. Abolhassani H11, 12
  17. Aghamohammadi A1, 3

Source: Allergologia et Immunopathologia Published:2020


Abstract

Background: Bacille Calmette-Guerin (BCG) vaccination has a great impact on the prevention of severe complications of tuberculosis. However, in patients with primary immunodeficiencies (PID), it can lead to severe complications such as severe combined immunodeficiency, chronic granulomatous disease, and Mendelian susceptibility to mycobacterial disease. This study highlights the demographics, clinical complications and laboratory parameters among PID patients associated with BCG vaccination side effects. Methods: One hundred and thirty-seven PID patients with BCGosis were evaluated in this study, based on the complications following BCG vaccination. Results: The mean age of the patients with BCG complications at the time of the first visit was five years. The within-group comparison of patients showed a highly significant incidence of pneumonia and hepatomegaly in severe combined immunodeficiency patients. Furthermore, the immunologic data showed an increase in the overall rates of lymphocytes such as CD3+, CD4+ and CD8 + T cells in Mendelian susceptibility to mycobacterial disease patients. The level of immunoglobulins has also increased in chronic granulomatous disease patients. Conclusion: The high rate of undiagnosed PIDs predisposes individuals to a high risk of severe side effects as a result of BCG vaccination, as well as infants that are less than one month of age. Therefore, there is a need for early screening and diagnosis of PIDs before exposing unknown PID status patients to BCG vaccination. The benefits of screening and early diagnosis of PID cannot be overemphasized, especially in patients with a previous family history of immunodeficiency. © 2020 SEICAP
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