Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri

Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri Publisher

Mortezazadeh T^{1, 2} ; Gholibegloo E³ ; Riyahi AN¹ ; Haghgoo S⁴ ; Musa AE¹ ; Khoobi M³

Source: Journal of Biomedical Physics and Engineering Published:2020

Abstract

Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas. Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2 O3) coated polycyclodextrin (PCD) and modified with glucose (Gd2 O3 @PCD-Glu) for the targeting of overexpressed glucose receptors. Material and Methods: In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd2 O3 @PCD-Glu NPs. Furthermore, the capacity of transporting Gd2 O3 @PCD-Glu NPs to tumor cells was evaluated. Results: It was found that the acquired MRI T1 signal intensity of MDA-MB-231 cells that were treated with the Gd2 O3 @PCD-Glu NPs increased significantly. Based on the results obtained, Gd2 O3 @PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis. Conclusion: Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity. © 2020, Shiraz University of Medical Sciences. All rights reserved.

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Mehdi Khoobi (12)

Hossein Ghanaati (4)

Style	Citing Format
MLA	Mortezazadeh T, et al.. "Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri." Journal of Biomedical Physics and Engineering, vol. 10, no. 1, 2020, pp. 25-38.
APA	Mortezazadeh T, Gholibegloo E, Riyahi AN, Haghgoo S, Musa AE, Khoobi M (2020). Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri. Journal of Biomedical Physics and Engineering, 10(1), 25-38.
Chicago	Mortezazadeh T, Gholibegloo E, Riyahi AN, Haghgoo S, Musa AE, Khoobi M. "Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri." Journal of Biomedical Physics and Engineering 10, no. 1 (2020): 25-38.
Harvard	Mortezazadeh T et al. (2020) 'Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri', Journal of Biomedical Physics and Engineering, 10(1), pp. 25-38.
Vancouver	Mortezazadeh T, Gholibegloo E, Riyahi AN, Haghgoo S, Musa AE, Khoobi M. Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri. Journal of Biomedical Physics and Engineering. 2020;10(1):25-38.
BibTex	@article{ author = {Mortezazadeh T and Gholibegloo E and Riyahi AN and Haghgoo S and Musa AE and Khoobi M}, title = {Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri}, journal = {Journal of Biomedical Physics and Engineering}, volume = {10}, number = {1}, pages = {25-38}, year = {2020} }
RIS	TY - JOUR AU - Mortezazadeh T AU - Gholibegloo E AU - Riyahi AN AU - Haghgoo S AU - Musa AE AU - Khoobi M TI - Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri JO - Journal of Biomedical Physics and Engineering VL - 10 IS - 1 SP - 25 EP - 38 PY - 2020 ER -

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